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聚维酮碘

聚维酮碘用途

Povidone iodine 显示出优异的抗细菌活性, 可以的杀死 MRSA 和 MSSA 菌株,其 MICs 值分别为 31.25 mg/L 和7.82 mg/L。

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聚维酮碘名称

[ CAS 号 ]:
25655-41-8

[ 中文名 ]:
聚乙烯吡咯烷酮碘络合物

[ 英文名 ]:
Povidone Iodine

[中文别名 ]:

聚维酮碘

[英文别名 ]:

Isobetadyne
Povidone-iodine
Disphex
Polyvinylpyrrolidone-Iodine Complex
PVP-I
Poly(vinylpyrrolidone)-Iodine complex
MFCD00084483
Povidone (iodinated)
EINECS 215-034-3
Poly(vinylpyrrolidone)–Iodine complex

聚维酮碘生物活性

[ 描述 ]:

Povidone iodine 显示出优异的抗细菌活性, 可以的杀死 MRSA 和 MSSA 菌株,其 MICs 值分别为 31.25 mg/L 和7.82 mg/L。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[体外研究]

聚维酮碘(PVP-1)的MIC值分别为31.25mg/L和7.82mg/L.用聚乙烯吡咯烷酮碘(PVP-I)以1:32的稀释度处理细胞导致所有测试细胞系的细胞活力急剧下降90-95％[1]。

[体内研究]

Dp +聚维酮碘(PVP-I)组从第13天到实验期结束的平均得分第二高。与对照组相比,Dp +聚维酮碘和Dp + Et-OH基团也显示嗜酸性粒细胞计数显着增加(分别为p <0.05和p <0.001)。然而,嗜酸性粒细胞计数在Dp +聚维酮碘(PVP-1),Dp + CHG和Dp +载体组之间没有显着差异[2]。

[细胞实验]

将每种细菌分离物用磷酸盐缓冲盐水（PBS，pH7.2）洗涤两次，在1932xg，20℃下离心10分钟，并悬浮在3mL营养肉汤中，调节至浊度当量为0.5McFarland标准。将细菌悬浮液用MHB以1：100稀释至106个菌落形成单位（cfu）/ mL的最终接种物。对于每种细菌菌株，用最终的细菌接种物（每孔50μL）和50μL的每种连续稀释的ILαD填充两排96孔微量滴定板。对聚维酮碘（PVP-I）系列稀释液重复该过程[1]。

[动物实验]

将小鼠分成如下6组：1）盐水+载体（对照组），2）Dp +载体，3）Dp + BZK，4）Dp +聚维酮碘（PVP-1），5）Dp + Et- OH，和6）Dp + CHG。实验组中的动物通过在麻醉下每周2至3天（总共8次）皮下注射溶解于右耳腹侧的10μL生理盐水中的5μgDp暴露于过敏原。％氟烷。对照组中的动物未致敏，在右耳腹侧接受10μL生理盐水的皮下注射。动物接受抗菌剂暴露于过敏原并用0.2％（w / v）苯扎氯铵（Dp + BZK），10％（w / v）聚维酮碘（Dp + PVP-I），80％处理（v / v）乙醇（Dp + Et-OH）或0.5％（v / v）葡萄糖酸氯己定（Dp + CHG）。这些试剂在实验期间共施用15次。将BZK，聚维酮碘（PVP-I），Et-OH和CHG溶解在25μL注射用水中，并使用具有细塑料尖端的微量移液管轻轻地施加到右耳的背侧。 Dp +载体和对照组中的动物接受25μL注射用水。在实验的最后一天（第18天）处死所有动物[2]。

[参考文献]

[1]. Zisi AP, et al. Iodine-lithium-alpha-dextrin (ILαD) against Staphylococcus aureus skin infections: a comparative study of in-vitro bactericidal activity and cytotoxicity between ILαD and povidone-iodine. J Hosp Infect. 2017 Jul 20. pii: S0195-6701(17)30395-X.

[2]. Kaori Sadakane, et al. Effect of the Hand Antiseptic Agents Benzalkonium Chloride, Povidone-Iodine, Ethanol, and Chlorhexidine Gluconate on Atopic Dermatitis in NC/Nga Mice. Int J Med Sci. 2015; 12(2): 116–125.

[相关活性小分子]

聚维酮碘物理化学性质

[ 沸点 ]:
217.6ºC at 760 mmHg

[ 熔点 ]:
300ºC

[ 分子式 ]:
C₆H₉I₂NO

[ 分子量 ]:
364.951

[ 闪点 ]:
93.9ºC

[ 精确质量 ]:
364.877319

[ PSA ]:
20.31000

[ LogP ]:
2.46160

[ 外观性状 ]:
一种红色-棕色结晶粉末

[ 蒸汽压 ]:
0.132mmHg at 25°C

[ 储存条件 ]:
室温

聚维酮碘MSDS

详细MSDS(安全技术说明书)

聚维酮碘毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TR1579600

CHEMICAL NAME :: Poly(1-(2-oxo-1-pyrrolidinyl)ethylene)iodine complex

CAS REGISTRY NUMBER :: 25655-41-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

DOSE/DURATION :: 3400 mg/kg/24H

TOXIC EFFECTS :: Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1450 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - physical

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 11600 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 11600 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 5000 ppm

REFERENCE :: APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A106,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0524 No. of Facilities: 1794 (estimated) No. of Industries: 14 No. of Occupations: 15 No. of Employees: 65694 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7540 No. of Facilities: 7099 (estimated) No. of Industries: 35 No. of Occupations: 49 No. of Employees: 1075065 (estimated) No. of Female Employees: 939668 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9186 No. of Facilities: 798 (estimated) No. of Industries: 3 No. of Occupations: 16 No. of Employees: 94521 (estimated) No. of Female Employees: 86562 (estimated)

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聚维酮碘安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TR1579600

[ 海关编码 ]:
3808940010

聚维酮碘海关

[ 海关编码 ]: 3808940010

聚维酮碘文献

Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats.

Fitoterapia 101 , 201-7, (2015)

Diplacone (1) and mimulone (2), two geranylated flavanones, have previously shown anti-inflammatory and antiradical activity in vitro. The present study aimed to evaluate their activity in vivo on a m...

Povidone-iodine and hydrogen peroxide mixture soaked gauze pack: a novel hemostatic technique.

J. Oral Maxillofac. Surg. 71(11) , 1833.e1-1833.e3, (2013)

Persistent oozing of blood is a common occurrence in maxillofacial surgery, and occasionally it hampers visibility and delays or even prevents continuation of the procedure. This report describes a no...

Effect of low-concentration povidone iodine on postoperative complications after third molar surgery: a pilot split-mouth study.

J. Oral Maxillofac. Surg. 73(1) , 18-21, (2015)

Povidone iodine is used primarily as an antiseptic to decrease surgical site infection. Its hemostatic and antiedematous properties in oral surgery also have been investigated recently.A randomized co...

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