< 生产厂家 价格 >

聚维酮碘

聚维酮碘用途

Povidone iodine 显示出优异的抗细菌活性, 可以的杀死 MRSA 和 MSSA 菌株,其 MICs 值分别为 31.25 mg/L 和7.82 mg/L。
点击显示

聚维酮碘名称

[ CAS 号 ]:
25655-41-8

[ 中文名 ]:
聚乙烯吡咯烷酮碘络合物

[ 英文名 ]:
Povidone Iodine

[中文别名 ]:

[英文别名 ]:

聚维酮碘生物活性

[ 描述 ]:

Povidone iodine 显示出优异的抗细菌活性, 可以的杀死 MRSA 和 MSSA 菌株,其 MICs 值分别为 31.25 mg/L 和7.82 mg/L。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌
研究领域 >> 感染

[体外研究]

聚维酮碘(PVP-1)的MIC值分别为31.25mg/L和7.82mg/L.用聚乙烯吡咯烷酮碘(PVP-I)以1:32的稀释度处理细胞导致所有测试细胞系的细胞活力急剧下降90-95%[1]。

[体内研究]

Dp +聚维酮碘(PVP-I)组从第13天到实验期结束的平均得分第二高。与对照组相比,Dp +聚维酮碘和Dp + Et-OH基团也显示嗜酸性粒细胞计数显着增加(分别为p <0.05和p <0.001)。然而,嗜酸性粒细胞计数在Dp +聚维酮碘(PVP-1),Dp + CHG和Dp +载体组之间没有显着差异[2]。

[细胞实验]

将每种细菌分离物用磷酸盐缓冲盐水(PBS,pH7.2)洗涤两次,在1932xg,20℃下离心10分钟,并悬浮在3mL营养肉汤中,调节至浊度当量为0.5McFarland标准。将细菌悬浮液用MHB以1:100稀释至106个菌落形成单位(cfu)/ mL的最终接种物。对于每种细菌菌株,用最终的细菌接种物(每孔50μL)和50μL的每种连续稀释的ILαD填充两排96孔微量滴定板。对聚维酮碘(PVP-I)系列稀释液重复该过程[1]。

[动物实验]

将小鼠分成如下6组:1)盐水+载体(对照组),2)Dp +载体,3)Dp + BZK,4)Dp +聚维酮碘(PVP-1),5)Dp + Et- OH,和6)Dp + CHG。实验组中的动物通过在麻醉下每周2至3天(总共8次)皮下注射溶解于右耳腹侧的10μL生理盐水中的5μgDp暴露于过敏原。 %氟烷。对照组中的动物未致敏,在右耳腹侧接受10μL生理盐水的皮下注射。动物接受抗菌剂暴露于过敏原并用0.2%(w / v)苯扎氯铵(Dp + BZK),10%(w / v)聚维酮碘(Dp + PVP-I),80%处理(v / v)乙醇(Dp + Et-OH)或0.5%(v / v)葡萄糖酸氯己定(Dp + CHG)。这些试剂在实验期间共施用15次。将BZK,聚维酮碘(PVP-I),Et-OH和CHG溶解在25μL注射用水中,并使用具有细塑料尖端的微量移液管轻轻地施加到右耳的背侧。 Dp +载体和对照组中的动物接受25μL注射用水。在实验的最后一天(第18天)处死所有动物[2]。

[参考文献]

[1]. Zisi AP, et al. Iodine-lithium-alpha-dextrin (ILαD) against Staphylococcus aureus skin infections: a comparative study of in-vitro bactericidal activity and cytotoxicity between ILαD and povidone-iodine. J Hosp Infect. 2017 Jul 20. pii: S0195-6701(17)30395-X.

[2]. Kaori Sadakane, et al. Effect of the Hand Antiseptic Agents Benzalkonium Chloride, Povidone-Iodine, Ethanol, and Chlorhexidine Gluconate on Atopic Dermatitis in NC/Nga Mice. Int J Med Sci. 2015; 12(2): 116–125.


[相关活性小分子]

嘌呤霉素二盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | 盐酸依拉环素 | 头孢噻肟钠

聚维酮碘物理化学性质

[ 沸点 ]:
217.6ºC at 760 mmHg

[ 熔点 ]:
300ºC

[ 分子式 ]:
C6H9I2NO

[ 分子量 ]:
364.951

[ 闪点 ]:
93.9ºC

[ 精确质量 ]:
364.877319

[ PSA ]:
20.31000

[ LogP ]:
2.46160

[ 外观性状 ]:
一种红色-棕色结晶粉末

[ 蒸汽压 ]:
0.132mmHg at 25°C

[ 储存条件 ]:
室温

聚维酮碘MSDS

聚维酮碘毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TR1579600
CHEMICAL NAME :
Poly(1-(2-oxo-1-pyrrolidinyl)ethylene)iodine complex
CAS REGISTRY NUMBER :
25655-41-8
LAST UPDATED :
199701
DATA ITEMS CITED :
22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
DOSE/DURATION :
3400 mg/kg/24H
TOXIC EFFECTS :
Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1450 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - physical
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
11600 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
11600 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
5000 ppm
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A106,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0524 No. of Facilities: 1794 (estimated) No. of Industries: 14 No. of Occupations: 15 No. of Employees: 65694 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7540 No. of Facilities: 7099 (estimated) No. of Industries: 35 No. of Occupations: 49 No. of Employees: 1075065 (estimated) No. of Female Employees: 939668 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9186 No. of Facilities: 798 (estimated) No. of Industries: 3 No. of Occupations: 16 No. of Employees: 94521 (estimated) No. of Female Employees: 86562 (estimated)
点击显示

聚维酮碘安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TR1579600

[ 海关编码 ]:
3808940010

聚维酮碘海关

[ 海关编码 ]: 3808940010

聚维酮碘文献

Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats.

Fitoterapia 101 , 201-7, (2015)

Diplacone (1) and mimulone (2), two geranylated flavanones, have previously shown anti-inflammatory and antiradical activity in vitro. The present study aimed to evaluate their activity in vivo on a m...

Povidone-iodine and hydrogen peroxide mixture soaked gauze pack: a novel hemostatic technique.

J. Oral Maxillofac. Surg. 71(11) , 1833.e1-1833.e3, (2013)

Persistent oozing of blood is a common occurrence in maxillofacial surgery, and occasionally it hampers visibility and delays or even prevents continuation of the procedure. This report describes a no...

Effect of low-concentration povidone iodine on postoperative complications after third molar surgery: a pilot split-mouth study.

J. Oral Maxillofac. Surg. 73(1) , 18-21, (2015)

Povidone iodine is used primarily as an antiseptic to decrease surgical site infection. Its hemostatic and antiedematous properties in oral surgery also have been investigated recently.A randomized co...


更多文献

推荐生产厂家/供应商:

公司名:南通润丰石油化工有限公司

区域:南通市崇川区

价格:
¥需询单/1kg ¥需询单/1ton

联系人:曹经理

产品详情:聚维酮碘


公司名:上海吉至生化科技有限公司

区域:上海市奉贤区

价格:
¥188.0/500g

联系人:刘佳

产品详情:聚乙烯吡咯烷酮碘络合物


公司名:上海脉铂医药科技有限公司

区域:上海市嘉定区

价格:
¥489.0/1g ¥389.0/500mg ¥需询单/1g ¥需询单/1g

联系人:李先生

产品详情:Povidone iodine


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥463.9/100g ¥1647.9/500g ¥545.9/1ml ¥5767.9/3kg

联系人:阿拉丁李高志

产品详情:聚乙烯吡咯烷酮碘络合物


公司名:上海创赛科技有限公司

区域:上海市嘉定区

价格:
¥74.0/100g ¥191.0/500g ¥692.0/2500g ¥490.0/1g

联系人:夏言

产品详情:[Perfemiker]聚乙烯吡咯烷酮碘络合物,试剂级


查看所有供应商请点击:

聚维酮碘供应商


相关化合物

【聚维酮碘】化源网提供聚维酮碘CAS号25655-41-8,聚维酮碘MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询聚维酮碘上化源网,专业又轻松。>>电脑版:聚维酮碘

标题:聚维酮碘_MSDS_用途_熔点_聚维酮碘CAS号【25655-41-8】_化源网 地址:https://m.chemsrc.com/mip/cas/25655-41-8_340383.html