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益康唑

益康唑用途

Econazole是一抗真菌化合物。

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益康唑名称

[ CAS 号 ]:
27220-47-9

[ 中文名 ]:
益康唑

[ 英文名 ]:
Econazole

[中文别名 ]:

双氯甲氧苯咪唑

[英文别名 ]:

EINECS 248-341-6
Econazole
Ecostatin
Gyno-Pevaryl
UNII:6Z1Y2V4A7M
Spectazole
Palavale
Epi-pevaryl
Ifenec
econazolum

益康唑生物活性

[ 描述 ]:

Econazole是一抗真菌化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[参考文献]

[1]. Thienpont D, et al. Bilogical and toxicological properties of econazole, a broad-spectrum antimycotic. Arzneimittelforschung. 1975 Feb;25(2):224-30.

[相关活性小分子]

益康唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
533.8±50.0 °C at 760 mmHg

[ 熔点 ]:
86.8ºC

[ 分子式 ]:
C₁₈H₁₅Cl₃N₂O

[ 分子量 ]:
381.684

[ 闪点 ]:
276.6±30.1 °C

[ 精确质量 ]:
380.024994

[ PSA ]:
27.05000

[ LogP ]:
5.32

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
室温，密封

益康唑MSDS

详细MSDS(安全技术说明书)

益康唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4767000

CHEMICAL NAME :: Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-

CAS REGISTRY NUMBER :: 27220-47-9

BEILSTEIN REFERENCE NO. :: 0964150

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H15-Cl3-N2-O

MOLECULAR WEIGHT :: 381.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 4,208,1989

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益康唑安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
24/25-36/37/39

益康唑文献

The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules.

J. Chromatogr. A. 1218(43) , 7886-94, (2011)

This study describes using 0.1% of a 28-30% ammonium hydroxide solution as an additive to alcohol modifiers in SFC to improve chromatographic peak shapes for basic molecules. Ammonium hydroxide's high...

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.

Sci. Rep. 4 , 5285, (2014)

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular ...

Effect of methoxychlor on Ca(2+) movement and viability in MDCK renal tubular cells.

Basic Clin Pharmacol Toxicol. 111(4) , 224-31, (2012)

The effect of the insecticide methoxychlor on the physiology of renal tubular cells is unknown. This study aimed to explore the effect of methoxychlor on cytosolic Ca(2+) concentrations ([Ca(2+) ](i) ...

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益康唑