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2,3-二氢-N,N-二甲基-2-氧代-3-[(4,5,6,7-四氢-1H-吲哚-2-基)亚甲基] -1H-吲哚-5-磺酰胺

用途

SU 6656是Src家族激酶抑制剂,抑制Src,Yes,Lyn,Fyn 的IC50分别为280,20,130,170 nM。

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名称

[ CAS 号 ]:
330161-87-0

[ 中文名 ]:
2,3-二氢-N,N-二甲基-2-氧代-3-[(4,5,6,7-四氢-1H-吲哚-2-基)亚甲基]-1H-吲哚-5-磺胺

[ 英文名 ]:
SU6656

[英文别名 ]:

SU6656

生物活性

[ 描述 ]:

SU 6656是Src家族激酶抑制剂,抑制Src,Yes,Lyn,Fyn 的IC50分别为280,20,130,170 nM。

[ 相关类别 ]:

信号通路 >> 蛋白酪氨酸激酶 >> SRC

研究领域 >> 癌症

[参考文献]

[1]. Blake RA, et al. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 2000 Dec;20(23):9018-27.

[2]. Veracini L, et al. Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. Oncotarget. 2014 Dec 26.

[3]. Wu ML, et al. Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014 Mar 28;12:22.

[4]. Ondrusová L, et al. Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells. Folia Biol (Praha). 2013;59(4):162-7.

[5]. Kumar A, et al. Pharmacological investigations on possible role of Src kinases in neuroprotective mechanism of ischemic postconditioning in mice. Int J Neurosci. 2014 Oct;124(10):777-86.

[6]. Liu XF, et al. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Mol Cancer Ther. 2014 Jan;13(1):82-9.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C₁₉H₂₁N₃O₃S

[ 分子量 ]:
371.453

[ 精确质量 ]:
371.130371

[ PSA ]:
90.65000

[ LogP ]:
3.46

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.657

[ 储存条件 ]:
-20℃

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
N

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Prolonged continuous in vitro human platelet production using three-dimensional scaffolds.

Exp. Hematol. 37(1) , 101-10, (2009)

Methods producing human platelets using growth on plastic, on feeder layers, or in suspension have been described. We hypothesized that growth of hematopoietic progenitors in a three-dimensional (3D) ...

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.

Nat. Commun. 5 , 5092, (2014)

Ovarian cancer is the most lethal gynaecologic malignancy in the United States, and advanced serous ovarian adenocarcinoma is responsible for most ovarian cancer deaths. However, the stroma-derived mo...

Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells.

Am. J. Physiol. Cell Physiol. 290(2) , C463-71, (2006)

Cortactin, a predominant substrate of Src family kinases, plays an important role in Arp2/3-dependent actin polymerization in lamellipodia and membrane ruffles and was recently shown to be enriched in...

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