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头孢孟多

头孢孟多用途

Cefamandole是第二代广谱头孢菌素类抗生素, 抗生素在体内分解, 释放游离NMTT, 可导致低凝血酶原血症。

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头孢孟多名称

[ CAS 号 ]:
34444-01-4

[ 中文名 ]:
头孢孟多

[ 英文名 ]:
Cefamandole

[中文别名 ]:

羟苄四唑头孢菌素

[英文别名 ]:

cefamandol
MFCD00056872
Florfenicol-d3 AMine
CEFAMANDOLE
cephadole
cephamandole
cefadole
EINECS 252-030-0

头孢孟多生物活性

[ 描述 ]:

Cefamandole是第二代广谱头孢菌素类抗生素, 抗生素在体内分解, 释放游离NMTT, 可导致低凝血酶原血症。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

头孢孟多物理化学性质

[ 密度 ]:
1.75 g/cm3

[ 分子式 ]:
C₁₈H₁₈N₆O₅S₂

[ 分子量 ]:
462.50300

[ 精确质量 ]:
462.07800

[ PSA ]:
201.14000

[ LogP ]:
0.10320

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
库房低温通风干燥

头孢孟多毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0383700

CHEMICAL NAME :: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-3- (((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6-alpha,7-beta(R*)))-

CAS REGISTRY NUMBER :: 34444-01-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H18-N6-O5-S2

MOLECULAR WEIGHT :: 462.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/5D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,660,1980 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 gm/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 8,280,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3194 No. of Facilities: 299 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16094 (estimated) No. of Female Employees: 13604 (estimated)