抑霉唑
抑霉唑用途
抑霉唑名称
[ CAS 号 ]:
35554-44-0
[ 中文名 ]:
抑霉唑
[ 英文名 ]:
Imazalil
[中文别名 ]:
[英文别名 ]:
- Eniloconazol
- Bromazil
- Fecundal
- EINECS 252-615-0
- Fcundal
- MFCD00055331
- FLO-PRO
- Fungazil
- Freshgard
- (RS)-1-(β-allyloxy-2,4-dichlorophenethyl)imidazole
抑霉唑生物活性
抑霉唑物理化学性质
[ 密度 ]:
1.348
[ 沸点 ]:
448.5±45.0 °C at 760 mmHg
[ 熔点 ]:
52.7°C
[ 分子式 ]:
C14H14Cl2N2O
[ 分子量 ]:
297.180
[ 闪点 ]:
225.1±28.7 °C
[ 精确质量 ]:
296.048309
[ PSA ]:
27.05000
[ LogP ]:
3.58
[ 外观性状 ]:
略黄色至棕色液体带有一种特有的气味
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.573
[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放
[ 水溶解性 ]:
0.018 g/100 mL
抑霉唑毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI4776000
- CHEMICAL NAME :
- 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-(2-propenyloxy)ethyl)-
- CAS REGISTRY NUMBER :
- 35554-44-0
- BEILSTEIN REFERENCE NO. :
- 0545683
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C14-H14-Cl2-N2-O
- MOLECULAR WEIGHT :
- 297.20
- WISWESSER LINE NOTATION :
- T5N CNJ A1YO2U1&R BG DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 227 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia Skin and Appendages - hair
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 gm/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,482,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,482,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 155 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia Skin and Appendages - hair
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >640 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A230,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3640 mg/kg/2Y-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2240 mg/kg
- SEX/DURATION :
- female 16-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 560 mg/kg
- SEX/DURATION :
- female 16-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4160 mg/kg
- SEX/DURATION :
- multigenerations
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - live birth index (measured after birth)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 8190 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 32500 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,309,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
抑霉唑安全信息
[ 符号 ]:
GHS05, GHS06, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H318-H332-H410
[ 警示性声明 ]:
Missing Phrase - N15.00950417-P261-P280-P305 + P351 + P338 + P310
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn;N
[ 风险声明 (欧洲) ]:
R20/22;R41;R50/53
[ 安全声明 (欧洲) ]:
S26-S39-S60-S61
[ 危险品运输编码 ]:
2588
[ RTECS号 ]:
NI4776000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2933290012
抑霉唑合成路线
抑霉唑上下游产品
抑霉唑上游产品
抑霉唑下游产品
抑霉唑制备
1. 2',2,4-三氯苯乙酮的制备14.7g间二氯苯与16.7g无水三氯化铝混合后，在搅拌下滴加12.6g氯乙酰氯。滴毕反应3h，水解、过滤、水洗、干燥后得粗品，用乙醇重结晶，收率83.7%。
2. 1-氯甲基-2,4-二氯苯甲醇的制备将上步产物６6.7g和无水甲醇混合，搅拌溶解。在冰水浴冷却下，分批加入硼氢化钠，加毕继续反应5min，加30mL水，再搅拌10min。蒸出甲醇，稀盐酸中和，过滤，干燥后得产品6.3g，收率93%。
3. 1-［2-（2,4-二氯苯基）-2-羟基乙基］-1H-咪唑的制备将２步产物1.0g、咪唑0.3g、有机胺0.2g、粉状氢氧化钠0.2g、有机溶剂5.5mL混合后，于70℃搅拌反应4h，冷却，加水30mL，过滤、干燥后得1g固体产物，收率87%。
4.抑霉唑的合成将3步产物0.5g、氯丙烯0.24g、粉状氢氧化钠0.1g、有机胺0.1g、有机溶剂5mL，搅拌反应24g，加入水、乙醚萃取，水洗至中性，干燥，脱溶得0.5g液体，收率86.5%。
制备方法二
抑霉唑海关
[ 海关编码 ]: 2933290012
[ 中文概述 ]:
2933290012 抑霉唑,咪菌腈,咪菌酮,咪鲜胺等〔包括克霉唑,咪鲜胺锰盐〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
[ 监管条件 ]: S.进出口农药登记证明
[ Summary ]:
2933290012 1-((2-chlorophenyl)diphenylmethyl)-1h-imidazole。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%
抑霉唑文献
J. Agric. Food Chem. 58(6) , 3661-6, (2010)
The postinfection activity of azoxystrobin (AZX), fludioxonil (FLU), and pyrimethanil (PYR), applied alone or in combination with imazalil (IMZ), in controlling postharvest green mold in 'Salustiana' ...
Inhibition of citrus fungal pathogens by using lactic acid bacteria.J. Food Sci. 75(6) , M354-9, (2010)
The effect of lactic acid bacteria (LAB) on pathogenic fungi was evaluated and the metabolites involved in the antifungal effect were characterized. Penicillium digitatum (INTA 1 to INTA 7) and Geotri...
Screening and identification of inhibitors against influenza A virus from a US drug collection of 1280 drugs.Antiviral Res. 109 , 54-63, (2014)
Infection with influenza A virus is still a global concern since it causes significant mortality, morbidity and economic loss. New burst pandemics and rapid emergence of drug-resistance strains in rec...
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相关药品：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：抑霉唑
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥238.0/1ml
￥238.0/1ml
联系人：刘佳
产品详情：抑霉唑标准溶液
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：Imazalil
公司名：上海脉铂医药科技有限公司
区域：上海市嘉定区
价格：
￥389.0/50mg
￥933.0/100mg
￥需询单/1g
￥需询单/1g
联系人：李先生
产品详情：Imazalil
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥370.9/1ml
￥411.9/100mg
￥205.9/1ml
￥需询单/1g
联系人：阿拉丁
产品详情：甲醇中抑霉唑溶液
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