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MethADP

MethADP用途

MethADP 是一个特异性的 CD73 抑制剂。

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MethADP名称

[ CAS 号 ]:
3768-14-7

[ 中文名 ]:
MethADP

[ 英文名 ]:
MethADP

[英文别名 ]:

Dimethylepoxypropionamide
3,3-Dimethyl-glycidsaeure-amid
Adenosine 5'-methylenediphosphate
2-Aminocarbonyl-3-methyloxiran
3,3-dimethyl-oxiranecarboxylic acid amide
2,3-Epoxy-3-methylbutyramide
Oxiranecarboxamide,3,3-dimethyl
BUTYRAMIDE,2,3-EPOXY-3-METHYL
Dimethylepoxypropionamide [French]

MethADP生物活性

[ 描述 ]:

MethADP 是一个特异性的 CD73 抑制剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 癌症

[ 靶点 ]

CD73[1].

[体外研究]

与A498和RT4细胞中的未处理对照(9.6±1.5μM)相比,MethADP(AMP-CP：20μM)引起腺苷形成的显着抑制(0.96±0.96μM),并且MethADP(100μM)完全抑制腺苷形成[ 1]。

[参考文献]

[1]. Mohlin C, et al. Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells. Pharmacology. 2009;84(4):196-202.

[相关活性小分子]

MethADP物理化学性质

[ 密度 ]:
2.35g/cm3

[ 沸点 ]:
895.6ºC at 760mmHg

[ 分子式 ]:
C₁₁H₁₇N₅O₉P₂

[ 分子量 ]:
425.22800

[ 闪点 ]:
495.4ºC

[ 精确质量 ]:
425.05000

[ PSA ]:
242.99000

[ 折射率 ]:
1.885

[ 储存条件 ]:
-20°C，干燥，密封

MethADPMSDS

详细MSDS(安全技术说明书)

MethADP安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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MethADP文献

Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase.

J. Med. Chem. 52 , 5485-95, (2009)

Mycobacterium tuberculosis adenosine-5'-phosphosulfate (APS) reductase is an iron-sulfur protein and a validated target to develop new antitubercular agents, particularly for the treatment of latent i...

Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.

Immunity 38(3) , 555-69, (2013)

Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood. Here, we show that although of common origin, the homing of proinflam...

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

Structure 20(12) , 2161-73, (2012)

In vertebrates ecto-5′-nucleotidase (e5NT) catalyzes the hydrolysis of extracellular AMP to adenosine and represents the major control point for extracellular adenosine levels. Due to its pivotal role...

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