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法呢醇

法呢醇用途

Farnesol 是一种半萜醇,能够调节细胞间的通讯,并具有抑菌活性。

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法呢醇名称

[ CAS 号 ]:
4602-84-0

[ 中文名 ]:
金合欢醇

[ 英文名 ]:
farnesol

[中文别名 ]:

[英文别名 ]:

(2-trans,6-trans)-farnesol
(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
Stirrup-TPW
Stirrup-HB
(2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trien-1-ol
(2E,6E)-Farnesol
all-trans-farnesol
all-E-Farnesol
Farnesoi
EINECS 225-004-1

法呢醇生物活性

[ 描述 ]:

Farnesol 是一种半萜醇,能够调节细胞间的通讯,并具有抑菌活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

天然产物 >> 萜类化合物和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

法尼醇是一种倍半萜烯醇,可调节白色念珠菌的细胞间通讯。还显示该分子对非白色念珠菌属物种,巴西Paracoccidioides brasiliensis和细菌具有抑制作用。最小抑制浓度(MIC)根据所述的M27-A3方案测定,法尼醇在0.29-150μM的浓度范围内测试。观察到法尼醇对新型隐球菌和C. gattii具有抑制活性(MIC范围：0.29-75.0μM)。虽然法尼醇不会显着改变磷脂酶活性,但观察到降低这种活性的趋势[1]。

[参考文献]

[1]. Cordeiro Rde A, et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. Vet Microbiol. 2012 Oct 12;159(3-4):375-80.

[相关活性小分子]

法呢醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
283.4±0.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₂₆O

[ 分子量 ]:
222.366

[ 闪点 ]:
96.1±0.0 °C

[ 精确质量 ]:
222.198364

[ PSA ]:
20.23000

[ LogP ]:
5.31

[ 外观性状 ]:
无色液体带有一种植物气味

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.485

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶；可溶于：醇

法呢醇MSDS

详细MSDS(安全技术说明书)

法呢醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR4979000

CHEMICAL NAME :: 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-

CAS REGISTRY NUMBER :: 4602-84-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H26-O

MOLECULAR WEIGHT :: 222.41

WISWESSER LINE NOTATION :: Q2UY1&3UY1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 443 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Insect - not otherwise specified Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 43,1285,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5190 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

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法呢醇安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H317-H319-H411

[ 警示性声明 ]:
P273-P280-P333 + P313-P337 + P313-P391-P501

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R24/25

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 3082 9 / PGIII

[ WGK德国 ]:
3

[ RTECS号 ]:
JR4979000

[ 海关编码 ]:
2905290000

法呢醇上下游产品

法呢醇上游产品

法呢醇下游产品

法呢醇海关

[ 海关编码 ]: 2905290000

[ 中文概述 ]:
2905290000 其他不饱和一元醇。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

法呢醇文献

Developmentally regulated sesquiterpene production confers resistance to Colletotrichum gloeosporioides in ripe pepper fruits.

PLoS ONE 9(10) , e109453, (2014)

Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol le...

Farnesol induces apoptosis-like cell death in the pathogenic fungus Aspergillus flavus.

Mycologia 106(5) , 881-8, (2014)

Farnesol (FOH) is known to induce apoptosis in some fungi and mammalian cells. We treated Aspergillus flavus, one of the leading causes of human invasive aspergillosis and a key producer of the most p...

Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms.

PLoS ONE 10 , e0133886, (2015)

Streptococcus mutans is the primary causative agent of dental caries, one of the most prevalent diseases in the United States. Previously published studies have shown that Pluronic-based tooth-binding...

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法呢醇