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2,5-二羟基苯甲酸

2,5-二羟基苯甲酸用途

2,5-Dihydroxybenzoic acid 是苯甲酸的代谢物,也是纤维母细胞生长因子 (fibroblast growth factor) 的强效抑制剂。

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2,5-二羟基苯甲酸名称

[ CAS 号 ]:
490-79-9

[ 中文名 ]:
2,5-二羟基苯甲酸

[ 英文名 ]:
Gentisic acid

[中文别名 ]:

[英文别名 ]:

Benzoic acid,2,5-dihydroxy
Gentistic acid
Gensigon
2,5-dihydroxyphenylcarboxylic acid
2,5-DHBA,DHB,Gentisic acid
Gensigen
2,5-Dihydroxybenzoic acid
Gentisate
2,5-Dhba
Hydroquinonecarboxylic acid

2,5-二羟基苯甲酸生物活性

[ 描述 ]:

2,5-Dihydroxybenzoic acid 是苯甲酸的代谢物,也是纤维母细胞生长因子 (fibroblast growth factor) 的强效抑制剂。

[ 相关类别 ]:

信号通路 >> 蛋白酪氨酸激酶 >> FGFR

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

Fibroblast growth factor

[体外研究]

2,5-二羟基苯甲酸(龙胆酸)是苯甲酸的衍生物,是阿司匹林代谢分解的次要产物[1]。 2,5-二羟基苯甲酸也是许多传统酒和草药的组成部分,被选为成纤维细胞生长因子的有力抑制剂。 2,5-二羟基苯甲酸用作铅以鉴定具有更好抑制特性的其他化合物,产生新的化学成分的成纤维细胞生长因子抑制剂,其包括负责尿黑酸尿症的药剂。通过低分辨率和高分辨率方法,使用成纤维细胞生长因子家族的代表成员及其细胞受体,显示这类抑制剂可以采用两种不同的机制来干扰触发成纤维细胞生长因子驱动的信号复合物的组装。有丝分裂发生[2]。

[体内研究]

从体内疾病模型证实,这组抑制剂(例如,2,5-二羟基苯甲酸)可能对治疗癌症和血管生成依赖性疾病感兴趣[2]。

[参考文献]

[1]. Levy G, et al. Salicylate accumulation kinetics in man. N Engl J Med. 1972 Aug 31;287(9):430-2.

[2]. IS Fernández, et al. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. Journal of Biological Chemistry , 2010, 285(15):11714-29.

[相关活性小分子]

2,5-二羟基苯甲酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
406.9±35.0 °C at 760 mmHg

[ 熔点 ]:
204-208 °C(lit.)

[ 分子式 ]:
C₇H₆O₄

[ 分子量 ]:
154.120

[ 闪点 ]:
214.0±22.4 °C

[ 精确质量 ]:
154.026611

[ PSA ]:
77.76000

[ LogP ]:
1.56

[ 外观性状 ]:
白色至黄色粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
室温

[ 水溶解性 ]:
soluble

2,5-二羟基苯甲酸MSDS

详细MSDS(安全技术说明书)

2,5-二羟基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LY3850000

CHEMICAL NAME :: Gentisic acid

CAS REGISTRY NUMBER :: 490-79-9

BEILSTEIN REFERENCE NO. :: 2209119

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C7-H6-O4

MOLECULAR WEIGHT :: 154.13

WISWESSER LINE NOTATION :: QVR BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 374 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 380 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 642 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2841 No. of Facilities: 22 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 38 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2841 No. of Facilities: 39 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 259 (estimated) No. of Female Employees: 60 (estimated)

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2,5-二羟基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LY3850000

[ 海关编码 ]:
29182990

2,5-二羟基苯甲酸合成路线

详细合成路线

2,5-二羟基苯甲酸上下游产品

2,5-二羟基苯甲酸上游产品

2,5-二羟基苯甲酸下游产品

2,5-二羟基苯甲酸制备

1. 由对苯二酚经羧基化而得。

2. 从水中得针晶。

3. 由氢酯制备。由过硫酸氧化水杨酸制备。

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2,5-二羟基苯甲酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

2,5-二羟基苯甲酸文献

Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase.

Nat. Commun. 6 , 5961, (2015)

Lytic polysaccharide monooxygenases (LPMOs) are recently discovered enzymes that oxidatively deconstruct polysaccharides. LPMOs are fundamental in the effective utilization of these substrates by bact...

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

Comparison of Mannose, Ethylene Glycol, and Methoxy-Terminated Diluents on Specificity and Selectivity of Electrochemical Peptide-Based Sensors.

Anal. Chem. 87 , 6966-73, (2015)

We report the synthesis and application of three new antifouling diluents for the fabrication of an E-PB HIV sensor. Among the three thiolated antifouling diluents used in this study, the methoxy-term...

更多文献

2,5-二羟基苯甲酸

2,5-二羟基苯甲酸用途

2,5-二羟基苯甲酸名称

2,5-二羟基苯甲酸生物活性

2,5-二羟基苯甲酸物理化学性质

2,5-二羟基苯甲酸MSDS

详细MSDS(安全技术说明书)

2,5-二羟基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2,5-二羟基苯甲酸安全信息

2,5-二羟基苯甲酸合成路线

详细合成路线

2,5-二羟基苯甲酸上下游产品

2,5-二羟基苯甲酸上游产品

2,5-二羟基苯甲酸下游产品

2,5-二羟基苯甲酸制备

2,5-二羟基苯甲酸海关

2,5-二羟基苯甲酸文献

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