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氢溴酸后马托品

氢溴酸后马托品用途

溴化Homatropine是毒蕈碱受体AChR拮抗剂。

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氢溴酸后马托品名称

[ CAS 号 ]:
51-56-9

[ 中文名 ]:
氢溴酸后马托品

[ 英文名 ]:
Homatropine (Bromide)

[中文别名 ]:

后马托品氢溴酸盐

[英文别名 ]:

EINECS 200-105-3
Homatropine hydrobromide
DL-Homatropine hydrobromide
MFCD00012676
Homatropine (Bromide)

氢溴酸后马托品生物活性

[ 描述 ]:

溴化Homatropine是毒蕈碱受体AChR拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. Leung, E. and F. Mitchelson, Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol, 1982. 80(1): p. 11-7.

[2]. Gilani, S.A. and L.B. Cobbin, Interaction of himbacine with carbachol at muscarinic receptors of heart and smooth muscle. Arch Int Pharmacodyn Ther, 1987. 290(1): p. 46-53.

[3]. Cramer, M.B., L.A. Cates, and D.E. Clarke, Rectal absorption of homatropine [14C]methylbromide in the rat. J Pharm Pharmacol, 1978. 30(5): p. 284-6.

[相关活性小分子]

氢溴酸后马托品物理化学性质

[ 密度 ]:
1.21g/cm3

[ 沸点 ]:
434.9ºC at 760 mmHg

[ 熔点 ]:
214-217 °C

[ 分子式 ]:
C₁₆H₂₂BrNO₃

[ 分子量 ]:
356.25500

[ 闪点 ]:
216.8ºC

[ 精确质量 ]:
355.07800

[ PSA ]:
49.77000

[ LogP ]:
2.78440

[ 外观性状 ]:
无色或白色粉末像溴一样的气味

[ 水溶解性 ]:
soluble

氢溴酸后马托品MSDS

详细MSDS(安全技术说明书)

氢溴酸后马托品毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM5602000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, mandelate (ester), hydrobromide

CAS REGISTRY NUMBER :: 51-56-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H21-N-O3.Br-H

MOLECULAR WEIGHT :: 356.30

WISWESSER LINE NOTATION :: T56 A ANTJ A1 GOVYQR &EH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 154 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,789,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 96,1,1949 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4753 No. of Facilities: 86 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 3286 (estimated) No. of Female Employees: 2698 (estimated)

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氢溴酸后马托品安全信息

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S45-S24/25-S22

[ 危险品运输编码 ]:
1544

[ RTECS号 ]:
YM5602000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933990090

氢溴酸后马托品上下游产品

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氢溴酸后马托品海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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