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大豆苷

大豆苷用途

大豆苷(Daidzin)是一种异黄酮具有抗氧化,抗癌,抗动脉粥样硬化活性。

大豆苷名称

[ CAS 号 ]:
552-66-9

[ 中文名 ]:
豆苷

[ 英文名 ]:
Daidzin

[中文别名 ]:

[英文别名 ]:

daidzein 7-O-β-D-glucoside
Daidzein 7-O-glucoside
4'-hydroxyisoflavone-7-O-glucoside
Daidzin
Daidzein-7-glucoside
4',7-hydroxyisoflavone-7-glucoside
MFCD00017466
Daidzein-7-O-β-D-glucopyranoside
4',7-dihydroxyisoflavone-7-D-glucoside
7-O-B-D-GLUCOPYRANOSIDE

大豆苷生物活性

[ 描述 ]:

大豆苷(Daidzin)是一种异黄酮具有抗氧化,抗癌,抗动脉粥样硬化活性。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 线粒体代谢

天然产物 >> 黄酮类化合物

研究领域 >> 其他

[参考文献]

[1]. Xie CI, et al. Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. Alcohol Clin Exp Res. 1994 Dec;18(6):1443-7.

[2]. Keung WM, et al. Kudzu root: an ancient Chinese source of modern antidipsotropic agents. Phytochemistry. 1998 Feb;47(4):499-506.

[3]. Keung WM, et al. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1675-9.

[相关活性小分子]

大豆苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
727.6±60.0 °C at 760 mmHg

[ 熔点 ]:
234-236°C

[ 分子式 ]:
C₂₁H₂₀O₉

[ 分子量 ]:
416.378

[ 闪点 ]:
259.8±26.4 °C

[ 精确质量 ]:
416.110718

[ PSA ]:
149.82000

[ LogP ]:
0.45

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.695

[ 储存条件 ]:
0-10°C;避免加热

大豆苷MSDS

大豆苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3094000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-5-hy droxy-

CAS REGISTRY NUMBER :: 552-66-9

BEILSTEIN REFERENCE NO. :: 0059741

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H20-O9

MOLECULAR WEIGHT :: 416.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979

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大豆苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DJ3094000

大豆苷合成路线

大豆苷上下游产品

大豆苷上游产品

大豆苷下游产品

大豆苷制备

分解点315-323℃，在高真空下可升华。紫外吸收峰250nm。存在于豆科植物野葛[Pueraria lobata(Willd) Ohwi]的根，豆科植物红车轴草(Trifolium pratense L.)全草，紫苜蓿(Medicago sativa L.)全草中。有雌激素样作用，合成的大豆黄素有明显的抗缺氧作用。

大豆苷文献

Comparing morphological, chemical and anti-diabetic characteristics of Puerariae Lobatae Radix and Puerariae Thomsonii Radix.

J. Ethnopharmacol. 164 , 53-63, (2015)

Puerariae Lobatae Radix (PLR) and Puerariae Thomsonii Radix (PTR) are traditional Chinese medicines used for the treatment of diabetes and cardiovascular diseases. These two herbs are used interchange...

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Fitoterapia 98 , 11-21, (2014)

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ...

Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with asymptomatic prostate cancer.

Cancer Prev. Res. (Phila.) 8 , 1045-54, (2015)

Epidemiologic associations suggest that populations consuming substantial amounts of dietary soy exhibit a lower risk of prostate cancer. A 20-week randomized, phase II, crossover trial was conducted ...

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大豆苷