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5-羰基-8-羟基喹啉

5-羰基-8-羟基喹啉用途

IOX1是2OG oxygenase高效广谱抑制剂,包括JmjC去甲基化酶家族,对KDM4A和KDM3A的IC50值分别为0.6uM和0.1uM。

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5-羰基-8-羟基喹啉名称

[ CAS 号 ]:
5852-78-8

[ 中文名 ]:
5-羰基-8-羟基喹啉

[ 英文名 ]:
5-Carboxy-8-hydroxyquinoline

[英文别名 ]:

8XQ
8-Hydroxy-chinolin-5-carbonsaeure
5-Quinolinecarboxylic acid, 8-hydroxy-
8-hydroxy-quinoline-5-carboxylic acid
UNII-JM015YQC1C
5-Carboxy-8-hydroxyquinoline
IOX1
8-Hydroxy-5-quinolinecarboxylic acid

5-羰基-8-羟基喹啉生物活性

[ 描述 ]:

IOX1是2OG oxygenase高效广谱抑制剂,包括JmjC去甲基化酶家族,对KDM4A和KDM3A的IC50值分别为0.6uM和0.1uM。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶

研究领域 >> 癌症

[参考文献]

[1]. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71.

[相关活性小分子]

5-羰基-8-羟基喹啉物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
464.5±30.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₇NO₃

[ 分子量 ]:
189.167

[ 闪点 ]:
234.7±24.6 °C

[ 精确质量 ]:
189.042587

[ PSA ]:
70.42000

[ LogP ]:
1.81

[ 外观性状 ]:
white to brown

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.730

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: soluble10mg/mL, clear

5-羰基-8-羟基喹啉MSDS

5-羰基-8-羟基喹啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933499090

5-羰基-8-羟基喹啉合成路线

5-羰基-8-羟基喹啉上下游产品

5-羰基-8-羟基喹啉上游产品

5-羰基-8-羟基喹啉下游产品

5-羰基-8-羟基喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羰基-8-羟基喹啉文献

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis.

Mol. Biol. Cell 25(8) , 1216-33, (2014)

The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling. Many histone-modifying enzy...

IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins.

Int. J. Mol. Med. 37 , 189-96, (2015)

The epigenetic modification of vascular smooth muscle cell (VSMC) phenotypic switching, proliferation, migration, apoptosis and extracellular matrix synthesis is known to occur in atherosclerosis. The...

A scintillation proximity assay for histone demethylases.

Anal. Biochem. 463 , 54-60, (2014)

Covalent modifications, such as methylation and demethylation of lysine residues in histones, play important roles in chromatin dynamics and the regulation of gene expression. The lysine demethylases ...

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