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盐酸阿那格雷

盐酸阿那格雷用途

Anagrelide(BL4162A)盐酸盐对血小板增多症有效。

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盐酸阿那格雷名称

[ CAS 号 ]:
58579-51-4

[ 中文名 ]:
盐酸阿那格雷

[ 英文名 ]:
Anagrelide HCl

[中文别名 ]:

[英文别名 ]:

MFCD01720337
Anagrelide Hydrochloride
Anagrelide (hydrochloride)

盐酸阿那格雷生物活性

[ 描述 ]:

Anagrelide(BL4162A)盐酸盐对血小板增多症有效。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 炎症/免疫

[参考文献]

[1]. Pescatore, S.L. and C. Lindley, Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother, 2000. 1(3): p. 537-46.

[2]. Petrides, P.E., Anagrelide: what was new in 2004 and 2005? Semin Thromb Hemost, 2006. 32(4 Pt 2): p. 399-408.

[相关活性小分子]

盐酸阿那格雷物理化学性质

[ 密度 ]:
1.77g/cm3

[ 沸点 ]:
376.5ºC at 760 mmHg

[ 熔点 ]:
>280ºC

[ 分子式 ]:
C₁₀H₈Cl₃N₃O

[ 分子量 ]:
292.549

[ 闪点 ]:
181.5ºC

[ 精确质量 ]:
290.973297

[ PSA ]:
44.70000

[ LogP ]:
2.43060

[ 外观性状 ]:
灰白色粉末

[ 储存条件 ]:
Desiccate at +4°C

盐酸阿那格雷MSDS

详细MSDS(安全技术说明书)

盐酸阿那格雷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5903250

CHEMICAL NAME :: Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride

CAS REGISTRY NUMBER :: 58579-51-4

LAST UPDATED :: 199109

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H7-Cl2-N3-O.Cl-H

MOLECULAR WEIGHT :: 292.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,277,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,277,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,277,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDADD8 New Drugs Annual: Cardiovascular Drugs. (New York, NY) V.1-2, 1983-84. For publisher information, see NCDREP. Volume(issue)/page/year: 1,277,1983

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盐酸阿那格雷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

盐酸阿那格雷合成路线

详细合成路线

盐酸阿那格雷上下游产品

盐酸阿那格雷上游产品

盐酸阿那格雷下游产品

盐酸阿那格雷海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸阿那格雷相关知识

盐酸阿那格雷的作用和用法用量

2022-04-27 19:37:01

阿那格雷(Anagrelide AG)是世界上唯一被美国FDA批准的可以治疗血发性血小板增多症的药物，该产品已经在加拿大、美国、英国、以色列上市，并获得美国 FDA、日本厚生省“唯一药物”待遇。原发性血小板增多症(ET)是Ph染色体阴性骨髓增殖性肿瘤(MPN)中的一种，该病起源于异常造血干细胞的克...