头孢哌酮钠

头孢哌酮钠用途

用作头孢类原料药及中间体。

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头孢哌酮钠作用

头孢哌酮钠（Cefoperazone sodium）头孢哌酮为第三代头孢菌素，对大肠埃希菌、克雷白菌属、变形杆菌属、伤寒沙门菌、志贺菌属、枸橼酸杆菌属等肠杆菌科细菌和铜绿假单胞菌有良好抗菌作用，对产气肠杆菌、阴沟肠杆菌、鼠伤寒杆菌和不动杆菌属等的作用较差。流感嗜血杆菌、淋病奈瑟菌和脑膜炎奈瑟菌对本品高度敏感。本品对各组链球菌、肺炎球菌亦有良好作用，对葡萄球菌（甲氧西林敏感株）仅具中度作用，肠球菌属耐药。头孢哌酮对多数革兰阳性厌氧菌和某些革兰阴性厌氧菌有良好作用，脆弱拟杆菌对本品耐药。在脑膜发炎时，可进入脑脊液。

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头孢哌酮钠名称

[ CAS 号 ]:
62893-20-3

[ 中文名 ]:
头孢哌酮钠

[ 英文名 ]:
Cefoperazone sodium

[中文别名 ]:

头孢哌酮钠盐

[英文别名 ]:

Cefoperazone sodium
MFCD07793331
cefoperazone-Na
Sodium cefoperazone
cefoperazone monosodium
EINECS 263-751-5
Tomabef
cephoperazone sodium
Cefoperazone sodium [USAN:JAN]
Cefoperazone sodium salt

头孢哌酮钠生物活性

[ 描述 ]:

Cefoperazone钠盐是一种头孢菌素类抗生素, 抑制rMrp2调节的 [3H]E217βG吸收, IC50为199 μM。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Kato, Y., et al., Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics. Drug Metab Dispos, 2008. 36(6): p. 1088-96.

[2]. Craig, W.A. and A.U. Gerber, Pharmacokinetics of cefoperazone: a review. Drugs, 1981. 22 Suppl 1: p. 35-45.

[相关活性小分子]

头孢哌酮钠物理化学性质

[ 熔点 ]:
200-202°C

[ 分子式 ]:
C₂₅H₂₆N₉NaO₈S₂

[ 分子量 ]:
667.649

[ 精确质量 ]:
667.124329

[ PSA ]:
273.69000

[ 外观性状 ]:
淡米色粉末

[ 储存条件 ]:
库房低温通风干燥

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, faintly yellow

头孢哌酮钠MSDS

详细MSDS(安全技术说明书)

头孢哌酮钠安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S22-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XI0374000

[ 海关编码 ]:
2941905600

头孢哌酮钠合成路线

详细合成路线

头孢哌酮钠上下游产品

头孢哌酮钠上游产品

头孢哌酮钠下游产品

头孢哌酮钠海关

[ 海关编码 ]: 2941905600

头孢哌酮钠文献

Housing conditions modulate the severity of Mycoplasma pulmonis infection in mice deficient in class A scavenger receptor.

Comp. Med. 64(6) , 424-39, (2014)

Mycoplasmosis is a frequent causative microbial agent of community-acquired pneumonia and has been linked to exacerbation of chronic obstructive pulmonary disease. The macrophage class A scavenger rec...

Randomized comparison of piperacillin-tazobactam plus amikacin versus cefoperazone-sulbactam plus amikacin for management of febrile neutropenia in children with lymphoma and solid tumors.

Pediatr. Hematol. Oncol. 30(2) , 141-8, (2013)

The objective of this study was to compare the effectiveness of piperacillin-tazobactam (PIP/TAZO) plus amikacin (AMK) (PIP/TAZO+AMK) versus cefoperazone-sulbactam (CS) plus AMK (CS+AMK) for the treat...

Interaction between caspofungin or voriconazole and cefoperazone-sulbactam or piperacillin-tazobactam by in vitro and in vivo methods.

APMIS 122(5) , 412-7, (2014)

Immunosuppressive patients are at risk of fungal and bacterial infections. Therefore, these patients receive prophylactic, preemptive, empirical or target antifungal and concomitant antibiotic therapy...

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