< 生产厂家价格 >

杀结核菌素

杀结核菌素用途

Tubercidin (7-Deazaadenosine)是一种腺苷类似物, 是从链霉菌tubercidicus中获得的抗生素。

点击显示

杀结核菌素名称

[ CAS 号 ]:
69-33-0

[ 中文名 ]:
杀结核菌素

[ 英文名 ]:
7-Deazaadenosine(Tubercidin)

[英文别名 ]:

EINECS 200-703-4
Tubercidine
sparsomycina
MFCD00056012
TUBERCIDIN
7-Deazaadenosine
Sparsomycine A

杀结核菌素生物活性

[ 描述 ]:

Tubercidin (7-Deazaadenosine)是一种腺苷类似物, 是从链霉菌tubercidicus中获得的抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

天然产物 >> 其他

研究领域 >> 感染

[参考文献]

[1]. Bloch A, et al. On the mode of action of 7-deaza-adenosine (Tubercidin). Biochim Biophys Acta. 1967 Mar 29;138(1):10-25.

[相关活性小分子]

杀结核菌素物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
648.8±55.0 °C at 760 mmHg

[ 熔点 ]:
247-248 °C (decomp)

[ 分子式 ]:
C₁₁H₁₄N₄O₄

[ 分子量 ]:
266.253

[ 闪点 ]:
346.2±31.5 °C

[ 精确质量 ]:
266.101501

[ PSA ]:
126.65000

[ LogP ]:
-0.12

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.834

[ 储存条件 ]:
室温

杀结核菌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8870000

CHEMICAL NAME :: 7H-Pyrrolo(2,3-d)pyrimidine, 4-amino-7-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 69-33-0

BEILSTEIN REFERENCE NO. :: 0038498

LAST UPDATED :: 199612

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C11-H14-N4-O4

MOLECULAR WEIGHT :: 266.29

WISWESSER LINE NOTATION :: T56 BN GN INJ FZ I- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - pleural effusion Gastrointestinal - other changes Lungs, Thorax, or Respiration - pleural effusion

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - pleural effusion Gastrointestinal - peritonitis Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28320 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rabbit Kidney

DOSE/DURATION :: 30 ug/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,1771,1989

点击显示

杀结核菌素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 3462 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UY8870000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29419090

杀结核菌素合成路线

详细合成路线

杀结核菌素上下游产品

杀结核菌素上游产品

杀结核菌素下游产品

杀结核菌素文献

Plasmodium falciparum: the potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials.

Exp. Parasitol. 132(4) , 440-3, (2012)

The anti-malarial activity of the cancer chemotherapeutic agent cisplatin and cisplatin analogues was determined in Plasmodium falciparum. The cisplatin analogues included DNA-targeted acridine-tether...

Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9.

Mol. Cancer Ther. 11(11) , 2321-30, (2012)

Despite significant treatment advances over the past decade, multiple myeloma (MM) remains largely incurable. In this study we found that MM cells were remarkably sensitive to the death-inducing effec...

Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases.

PLoS ONE 7(9) , e44282, (2012)

The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti...

更多文献