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青霉素钠

青霉素钠用途

Penicillin G sodium salt 是一种典型的 β-内酰胺类抗生素。
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青霉素钠名称

[ CAS 号 ]:
69-57-8

[ 中文名 ]:
青霉素G钠

[ 英文名 ]:
Penicillin G Sodium Salt

[中文别名 ]:

[英文别名 ]:

青霉素钠生物活性

[ 描述 ]:

Penicillin G sodium salt 是一种典型的 β-内酰胺类抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌
研究领域 >> 感染

[体外研究]

青霉素G钠盐-TEM-1体系的紫外-可见(UV-Vis)吸收光谱与青霉素G钠盐和TEM-1β-内酰胺酶的紫外-可见(UV-Vis)吸收光谱明显不同,表明青霉素G钠之间形成新的复合物。盐和TEM-1β-内酰胺酶。随着青霉素G钠盐浓度的增加,TEM-1β-内酰胺酶的紫外-可见吸收增加,并发生轻微的红移,表明青霉素G钠盐与TEM-1β-内酰胺酶之间的相互作用导致微妙的构象。 TEM-1β-内酰胺酶的变化[1]。

[体内研究]

在Logistic回归模型中,对照组阳性拭子的概率比用青霉素G钠盐处理的猪高1.6倍(P <0.05)。在对照组中,每个平板具有10至99个菌落的拭子与每个平板具有零的风险相比,是用青霉素G钠盐处理的猪的2.3倍(P = 0.022)[2]。

[激酶实验]

在278K，将各种浓度的青霉素G钠盐，头孢氨苄和头孢西丁溶液加入到TEM-1β-内酰胺酶溶液（5×10-6M）中。三种抗生素的浓度从0逐渐增加到25×10-6M。在混合和相互作用2分钟后，在具有2nm狭缝的分光光度计上记录紫外 - 可见（UV-Vis）吸收光谱。使用0.02M磷酸盐缓冲液（pH7.0）作为参考[1]，扫描速度为400nm / min。

[动物实验]

本研究使用具有2个重复的随机完整区组设计。每个重复包括448头猪，每支笔有16支笔和28头猪。猪也按重量分类;使得基于视觉观察的相似重量的动物在块内组合在一起。使用正式随机化过程在2个连续笔的每个块内随机分配两种处理。治疗组是对照（未给予治疗）和治疗（青霉素G钠盐）。青霉素G钠盐在2个治疗期间通过饮用水给药5天。第一个治疗期从断奶当天开始，当时猪被移入托儿所（第1天）并在第5天结束。第二个治疗期从第21天开始到第25天结束。对照组未接受治疗治疗[2]。

[参考文献]

[1]. Yang J, et al. Spectroscopic analysis and docking simulation on the recognition and binding of TEM-1 β-lactamase with β-lactam antibiotics. Exp Ther Med. 2017 Oct;14(4):3288-3298.

[2]. Byra C, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6.


[相关活性小分子]

嘌呤霉素二盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | 盐酸依拉环素 | 头孢噻肟钠

青霉素钠物理化学性质

[ 密度 ]:
1.41

[ 沸点 ]:
663.3ºC at 760 mmHg

[ 熔点 ]:
209-212°C

[ 分子式 ]:
C16H17N2NaO4S

[ 分子量 ]:
356.372

[ 精确质量 ]:
356.080658

[ PSA ]:
114.84000

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 折射率 ]:
300 ° (C=2, H2O)

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
5-10 g/100 mL at 25 ºC

青霉素钠MSDS

详细MSDS(安全技术说明书)

青霉素钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH9800000
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenyl acetamido)-, monosodium salt
CAS REGISTRY NUMBER :
69-57-8
LAST UPDATED :
199706
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C16-H17-N2-O4-S.Na
MOLECULAR WEIGHT :
356.40
WISWESSER LINE NOTATION :
T45 ANV ESTJ CMV1R& F1 F1 GVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6916 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - other changes
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946- Volume(issue)/page/year: 39,259,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3020 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,863,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 3,540,1955/1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 3,540,1955/1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,23,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3800 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,23,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Nutritional and Gross Metabolic - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LBASAE Laboratory Animal Science. (American Assoc. for Laboratory Animal Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435) V.21- 1971- Volume(issue)/page/year: 30,524,1980 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1840 mg/kg/46W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 15,85,1961 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 6-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,815,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1500 mg/kg
SEX/DURATION :
female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,815,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
30 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 158,528,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4380 No. of Facilities: 137 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 7315 (estimated) No. of Female Employees: 5985 (estimated)
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青霉素钠安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S22-S36/37-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XH9800000

[ 海关编码 ]:
2941109900

青霉素钠上下游产品

青霉素钠上游产品

青霉素钠下游产品

青霉素钠制备

采用产黄青霉菌（penicilumchryso-genum）的杂交菌株，经自然分离得到的黄孢菌种，通过微生物发酵制取。

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青霉素钠海关

[ 海关编码 ]: 2941109900

青霉素钠文献

Chronic inflammatory demyelinating polyneuropathy associated with neurosyphilis.

Am. J. Med. Sci. 349(1) , 90-1, (2015)

Determination of penicillin G in milk samples using its effect on cloud point extraction of triiodide ion.

J. AOAC Int. 97(4) , 1225-9, (2014)

A cloud point extraction (CPE) method for determination of trace amounts of penicillin G by spectrophotometry based on its effect on the triiodide ion (I3(-)) has been developed. Penicillin G is conve...

Skin testing only with penicillin G in children with a history of penicillin allergy.

Ann. Allergy Asthma Immunol. 113(1) , 75-81, (2014)

The absence of commercially available penicilloyl-polylysine (PPL) for most of the last decade severely hampered the practice of penicillin allergy evaluation because skin testing without PPL is repor...


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推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：青霉素钠

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥228.0/100mg ￥118.0/5g ￥388.0/25g

联系人：刘佳

产品详情：青霉素G钠盐

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥489.0/1g ￥389.0/100mg ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Penicillin G Sodium

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥197.9/100g ￥65.9/25g ￥37.9/5g ￥638.9/100mg

联系人：阿拉丁

产品详情：青霉素G钠

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相关化合物

【青霉素钠】化源网提供青霉素钠CAS号69-57-8，青霉素钠MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询青霉素钠上化源网，专业又轻松。>>电脑版：青霉素钠

标题：青霉素钠_MSDS_用途_密度_青霉素钠CAS号【69-57-8】_化源网 地址：https://m.chemsrc.com/mip/cas/69-57-8_946917.html