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甲磺酸培氟沙星

甲磺酸培氟沙星用途

Pefloxacin是抗菌化合物,通过抑制DNA旋转酶来阻断DNA复制。

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甲磺酸培氟沙星名称

[ CAS 号 ]:
70458-95-6

[ 中文名 ]:
甲磺酸培氟沙星

[ 英文名 ]:
Pefloxacin mesylate

[中文别名 ]:

[英文别名 ]:

EINECS 274-613-9
MFCD00865015
Pefloxacin mesylate

甲磺酸培氟沙星生物活性

[ 描述 ]:

Pefloxacin是抗菌化合物,通过抑制DNA旋转酶来阻断DNA复制。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

天然产物 >> 其他

[参考文献]

[1]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.

[2]. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

[相关活性小分子]

甲磺酸培氟沙星物理化学性质

[ 密度 ]:
1.32 g/cm3

[ 沸点 ]:
529.1ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₂₄FN₃O₆S

[ 分子量 ]:
429.463

[ 闪点 ]:
273.8ºC

[ 精确质量 ]:
429.136993

[ PSA ]:
128.53000

[ LogP ]:
2.19820

[ 储存条件 ]:
-20°C

甲磺酸培氟沙星毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB2002200

CHEMICAL NAME :: 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperaziny l)-4-oxo-, monomethanesulfonate, dihydrate

CAS REGISTRY NUMBER :: 70458-95-6

LAST UPDATED :: 199009

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H20-F-N3-O3.C-H4-O3-S.2H2-O

MOLECULAR WEIGHT :: 465.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981

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甲磺酸培氟沙星安全信息

[ 危害码 (欧洲) ]:
F,C

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
16-26-36/37/39-45

[ 海关编码 ]:
2933599090

甲磺酸培氟沙星海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%