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盐酸林可霉素

盐酸林可霉素用途

Lincomycin盐酸一水合物是窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌具有很好的作用效果, 主要抑制细菌细胞蛋白质的合成。

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盐酸林可霉素名称

[ CAS 号 ]:
7179-49-9

[ 中文名 ]:
6-(1-甲-反-丙基-L-2-吡咯烷甲酰氨基)-1-硫代-6,8-二脱氧-D-赤式-α-D-半乳辛吡喃糖苷盐酸一水合物

[ 英文名 ]:
Lincomycin Hydrochloride Monohydrate

[中文别名 ]:

[英文别名 ]:

Lincomycin hydrochloride monohydrate
EINECS 212-726-7
Frademicina
MFCD00167245
Waynecomycin
mycivin
Cillimycin
Lincomix
Lincomycin, hydrochloride hydrate
Lincomycin (hydrochloride hydrate)

盐酸林可霉素生物活性

[ 描述 ]:

Lincomycin盐酸一水合物是窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌具有很好的作用效果, 主要抑制细菌细胞蛋白质的合成。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

盐酸林可霉素物理化学性质

[ 沸点 ]:
646.8ºC at 760 mmHg

[ 熔点 ]:
154 °C

[ 分子式 ]:
C₁₈H₃₇ClN₂O₇S

[ 分子量 ]:
461.014

[ 闪点 ]:
345ºC

[ 精确质量 ]:
460.200989

[ PSA ]:
157.02000

[ LogP ]:
0.20950

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
2-8°C

盐酸林可霉素MSDS

详细MSDS(安全技术说明书)

盐酸林可霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RH6315500

CHEMICAL NAME :: D-erythro-D-Galacto-octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl- 2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, hemihydrate

CAS REGISTRY NUMBER :: 7179-49-9

LAST UPDATED :: 199512

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H34-N2-O6-S.Cl-H.H2-O

MOLECULAR WEIGHT :: 461.08

WISWESSER LINE NOTATION :: T6OTJ BS1 CQ DQ EQ FYYQ1&MV- BT5NTJ A1 D3 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 192 mg/kg/8D-I

TOXIC EFFECTS :: Blood - normocytic anemia

REFERENCE :: PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 59,796,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9778 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,65,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 342 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,891,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 214 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,891,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1523 No. of Facilities: 56 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4111 (estimated) No. of Female Employees: 3872 (estimated)

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盐酸林可霉素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RH6315500

盐酸林可霉素文献

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Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants.

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Pharmaceutically active compounds (PACs) are continuously dispersed into the environment due to human and veterinary use, giving rise to their potential accumulation in edible plants. In this study, E...

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