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Phenylpiracetam(Phenotropyl; Phenotropil)是piracetam的苯基衍生物,活性较piracetam高30到60倍。

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卡非多名称

[ CAS 号 ]:
77472-70-9

[ 中文名 ]:
4-苯基-2-吡咯烷酮-1-乙酰胺

[ 英文名 ]:
Carphedon

[中文别名 ]:

[英文别名 ]:

fonturacetam
UNII:99QW5JU66Y
Carphedon
Phenylpiracetam
4-Phenyl-2-pyrrolidone-1-acetamide
2-(2-Oxo-4-phenyl-1-pyrrolidinyl)acetamide
1-Pyrrolidineacetamide, 2-oxo-4-phenyl-
2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide
4-Phenylpiracetam
Phenotropil

卡非多生物活性

[ 描述 ]:

Phenylpiracetam(Phenotropyl; Phenotropil)是piracetam的苯基衍生物,活性较piracetam高30到60倍。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[参考文献]

[1]. Zvejniece L, et al. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):407-12.

[相关活性小分子]

卡非多物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
486.4±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₂H₁₄N₂O₂

[ 分子量 ]:
218.252

[ 闪点 ]:
247.9±28.7 °C

[ 精确质量 ]:
218.105530

[ PSA ]:
64.39000

[ LogP ]:
0.16

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.580

卡非多毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9663000

CHEMICAL NAME :: 1-Pyrrolidineacetamide, 2-oxo-4-phenyl-

CAS REGISTRY NUMBER :: 77472-70-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H14-N2-O2

MOLECULAR WEIGHT :: 218.28

WISWESSER LINE NOTATION :: T5NVTJ A1VZ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,776,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Behavioral - analgesia

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 44,22,1981

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卡非多安全信息

[ 海关编码 ]:
2933990090

卡非多合成路线

详细合成路线

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卡非多海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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