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对羟基苯甲酸丙酯

对羟基苯甲酸丙酯用途

Propylparaben 是一种抗菌剂、防腐剂、调味剂。

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对羟基苯甲酸丙酯名称

[ CAS 号 ]:
94-13-3

[ 中文名 ]:
尼泊金丙酯

[ 英文名 ]:
Propyl paraben

[中文别名 ]:

[英文别名 ]:

Propyl parahydroxybenzoate
Propyl-4-hydroxybenzoate
Mekkings P
4-hydroxybenzoic acid propyl ester
nipaginp
PROPYL PARASEPT
Nipasol M
Benzoic acid, p-hydroxy-, propyl ester
N-Propyl-p-hydroxybenzoate
Propyl chemosept

对羟基苯甲酸丙酯生物活性

[ 描述 ]:

Propylparaben 是一种抗菌剂、防腐剂、调味剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

天然产物 >> 其他

研究领域 >> 感染

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

对羟基苯甲酸丙酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
294.3±13.0 °C at 760 mmHg

[ 熔点 ]:
95-98 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂O₃

[ 分子量 ]:
180.201

[ 闪点 ]:
124.6±12.6 °C

[ 精确质量 ]:
180.078644

[ PSA ]:
46.53000

[ LogP ]:
2.93

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
库房低温,通风,干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
<0.1 g/100 mL at 12 ºC

对羟基苯甲酸丙酯MSDS

对羟基苯甲酸丙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2800000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, propyl ester

CAS REGISTRY NUMBER :: 94-13-3

BEILSTEIN REFERENCE NO. :: 1103245

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H12-O3

MOLECULAR WEIGHT :: 180.22

WISWESSER LINE NOTATION :: QR DVO3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6332 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946- Volume(issue)/page/year: 28,463,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,135,1960

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 146,208,1929 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80496 No. of Facilities: 2827 (estimated) No. of Industries: 21 No. of Occupations: 36 No. of Employees: 48242 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80496 No. of Facilities: 13566 (estimated) No. of Industries: 86 No. of Occupations: 117 No. of Employees: 526606 (estimated) No. of Female Employees: 355310 (estimated)

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对羟基苯甲酸丙酯安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
DH2800000

[ 海关编码 ]:
2918290000

对羟基苯甲酸丙酯合成路线

对羟基苯甲酸丙酯上下游产品

对羟基苯甲酸丙酯上游产品

对羟基苯甲酸丙酯下游产品

对羟基苯甲酸丙酯制备

1.由对羟基苯甲酸与正丙醇酯化而得。将对羟基苯甲酸和丙醇混合，加热使溶解，慢慢加入硫酸，继续加热回流8h后冷却，倒入4%碳酸钠溶液中析出结晶，过滤，水洗至中性即为粗品，再经乙醇重结晶而得成品。制备中，也可采用阳离子交换树脂代替硫酸催化剂。

2.由对羟基苯甲酸与正丙醇酯化，经脱色、重结晶制得。

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对羟基苯甲酸丙酯海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

对羟基苯甲酸丙酯文献

Development and validation of a stability-indicating LC-UV method for the determination of pantethine and its degradation product based on a forced degradation study.

J. Pharm. Biomed. Anal. 97 , 141-50, (2014)

Pantethine (d-bis-(N-pantothenyl-β-aminoethyl)-disulfide, PAN), the stable disulfide form of pantetheine, has beneficial effects in vascular diseases being able to decrease the hyperlipidaemia, modera...

Development and application of a validated stability-indicating high-performance liquid chromatographic method using photodiode array detection for simultaneous determination of granisetron, methylparaben, propylparaben, sodium benzoate, and their main degradation products in oral pharmaceutical preparations.

J. AOAC Int. 94(5) , 1447-60, (2011)

A simple, rapid, and sensitive RP-HPLC method using photodiode array detection was developed and validated for the simultaneous determination of granisetron hydrochloride, 1-methyl-1H-indazole-3-carbo...

The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

Altern. Lab. Anim. 43 , 101-27, (2015)

The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the hum...

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对羟基苯甲酸丙酯

对羟基苯甲酸丙酯用途

对羟基苯甲酸丙酯名称

对羟基苯甲酸丙酯生物活性

对羟基苯甲酸丙酯物理化学性质

对羟基苯甲酸丙酯MSDS

详细MSDS(安全技术说明书)

对羟基苯甲酸丙酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

对羟基苯甲酸丙酯安全信息

对羟基苯甲酸丙酯合成路线

详细合成路线

对羟基苯甲酸丙酯上下游产品

对羟基苯甲酸丙酯上游产品

对羟基苯甲酸丙酯下游产品

对羟基苯甲酸丙酯制备

对羟基苯甲酸丙酯海关

对羟基苯甲酸丙酯文献

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