N,N-二乙基-4-氨基苯甲醛

N,N-二乙基-4-氨基苯甲醛用途

4-Diethylaminobenzaldehyde 是一种可逆的醛脱氢酶 (ALDHs) 抑制剂,对 ALDH1 的 Ki 为 4 nM。4-Diethylaminobenzaldehyde 具有较强的抗雄激素作用 (IC50= 1.71 μM)。

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N,N-二乙基-4-氨基苯甲醛名称

[ CAS 号 ]:
120-21-8

[ 中文名 ]:
N,N-二乙基-4-氨基苯甲醛

[ 英文名 ]:
4-Diethylaminobenzaldehyde

[中文别名 ]:

[英文别名 ]:

Benzaldehyde, 4-(diethylamino)-
MFCD00003382
4-Diethylaminobenzaldehyde
4-Diethylaminobenzoaldehyde
4-(Diethylamino)benzaldehyde
EINECS 204-377-4
p-(Diethylamino)benzaldehyde
4-(Diethylamino)-Benzaldehyde
Benzaldehyde, p-(diethylamino)-

N,N-二乙基-4-氨基苯甲醛生物活性

[ 描述 ]:

4-Diethylaminobenzaldehyde 是一种可逆的醛脱氢酶 (ALDHs) 抑制剂,对 ALDH1 的 Ki 为 4 nM。4-Diethylaminobenzaldehyde 具有较强的抗雄激素作用 (IC50= 1.71 μM)。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 醛脱氢酶(ALDH)

研究领域 >> 癌症

[体外研究]

4-二乙氨基苯甲醛(DEAB)是ALDH1(与醛基竞争)的可逆竞争性抑制剂,Ki值为4nm,通过形成稳定的共价酰基酶物种不可逆地灭活ALDH7A1[1]。对替莫唑胺(TMZ)耐药细胞株LN18用TMZ和4-二乙氨基苯甲醛联合处理10天。如菌落形成试验所示,TMZ与4-二乙氨基苯甲醛(DEAB)联合作用后,LN18细胞的克隆形成能力明显减弱[3]。

[参考文献]

[1]. Luo M, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7.

[2]. Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42.

N,N-二乙基-4-氨基苯甲醛物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
329.6±0.0 °C at 760 mmHg

[ 熔点 ]:
37-41 °C(lit.)

[ 分子式 ]:
C₁₁H₁₅NO

[ 分子量 ]:
177.243

[ 闪点 ]:
110.2±12.0 °C

[ 精确质量 ]:
177.115356

[ PSA ]:
20.31000

[ LogP ]:
2.87

[ 外观性状 ]:
棕色-黑色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.571

[ 储存条件 ]:
室温

[ 水溶解性 ]:
insoluble

N,N-二乙基-4-氨基苯甲醛MSDS

N,N-二乙基-4-氨基苯甲醛安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H312-H315-H319-H335

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R21/22;R50/53

[ 安全声明 (欧洲) ]:
S26-S36-S61-S60-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
CU5612850

[ 海关编码 ]:
2922399090

N,N-二乙基-4-氨基苯甲醛合成路线

N,N-二乙基-4-氨基苯甲醛上下游产品

N,N-二乙基-4-氨基苯甲醛上游产品

N,N-二乙基-4-氨基苯甲醛下游产品

N,N-二乙基-4-氨基苯甲醛制备

将二乙基苯胺、乌洛托品和90%乙醇混匀，加热回流，加入冰乙酸和90%甲酸，保温过夜。将反应液倾入预冷的盐酸中，过滤，粗品经酸碱重结晶、乙醇重结晶得对二乙氨基苯甲醛。

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N,N-二乙基-4-氨基苯甲醛海关

[ 海关编码 ]: 2922399090

[ 中文概述 ]:
2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N,N-二乙基-4-氨基苯甲醛文献

Formation of spherical cancer stem-like cell colonies with resistance to chemotherapy drugs in the human malignant fibrous histiocytoma NMFH-1 cell line.

Oncol. Lett. 10 , 3323-3331, (2016)

Various human cancers have been revealed to contain cancer stem-like cells (CSCs) and the spherical colonies that possess stem-like properties and cancer-initiating abilities. Malignant fibrous histio...

Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers.

J. Med. Chem. 58 , 7949-58, (2015)

A series of bis(arylidene)cycloalkanone photosensitizers modified by polyethylene glycol (PEG) have been studied for two-photon excited photodynamic therapy (2PE-PDT). As compared with their prototype...

The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish.

Mech. Dev. 138 Pt 3 , 328-35, (2015)

The zebrafish pronephric tubule consists of proximal and distal segments and a collecting duct. The proximal segment is subdivided into the neck, proximal convoluted tubule (PCT) and proximal straight...

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