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补骨脂酚

补骨脂酚用途

补骨脂酚(Bakuchiol)是一种从补骨脂种子中植物雌激素,具有抗肿瘤等作用。

补骨脂酚名称

[ CAS 号 ]:
10309-37-2

[ 中文名 ]:
补骨脂酚

[ 英文名 ]:
Bakuchiol

[中文别名 ]:

[英文别名 ]:

BACTRIS GASIPAES FRUIT JUICE
Backuchiol
Bakuchiol
Drupanol
(S)-bakuchiol
UP 256

补骨脂酚生物活性

[ 描述 ]:

补骨脂酚(Bakuchiol)是一种从补骨脂种子中植物雌激素,具有抗肿瘤等作用。

[ 相关类别 ]:

信号通路 >> MAPK/ERK信号通路 >> p38 MAPK

研究领域 >> 癌症

天然产物 >> 萜类化合物和糖苷

[参考文献]

[1]. Chen Z, et al. Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol. 2010 Sep 25;643(2-3):170-9.

[2]. Xu Y, et al. In vitro evidence for bakuchiol's influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr Health Sci. 2014 Sep;14(3):564-9.

[3]. Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106.

[4]. Lau KM, et al. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine. 2014 Jun 15;21(7):942-5.

[相关活性小分子]

补骨脂酚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
391.4±21.0 °C at 760 mmHg

[ 分子式 ]:
C₁₈H₂₄O

[ 分子量 ]:
256.383

[ 闪点 ]:
176.6±11.7 °C

[ 精确质量 ]:
256.182709

[ PSA ]:
20.23000

[ LogP ]:
6.40

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
通风低温干燥

补骨脂酚MSDS

详细MSDS(安全技术说明书)

补骨脂酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL3785000

CHEMICAL NAME :: Phenol, 4-(3-ethenyl-3,7-dimethyl-1,6-octadienyl)-, (S-(E))-

CAS REGISTRY NUMBER :: 10309-37-2

LAST UPDATED :: 199801

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H24-O

MOLECULAR WEIGHT :: 256.42

WISWESSER LINE NOTATION :: QR D1U1X1&1U1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MZHUDX Mikrobiologicheskii Zhurnal (Kiev). Journal of Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.40- 1978- Volume(issue)/page/year: 42,646,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MZHUDX Mikrobiologicheskii Zhurnal (Kiev). Journal of Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.40- 1978- Volume(issue)/page/year: 42,646,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MZHUDX Mikrobiologicheskii Zhurnal (Kiev). Journal of Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.40- 1978- Volume(issue)/page/year: 42,646,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MZHUDX Mikrobiologicheskii Zhurnal (Kiev). Journal of Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.40- 1978- Volume(issue)/page/year: 42,646,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg/10D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: MZHUDX Mikrobiologicheskii Zhurnal (Kiev). Journal of Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.40- 1978- Volume(issue)/page/year: 42,646,1980

补骨脂酚安全信息

[ 危害码 (欧洲) ]:
F+

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SL3785000

[ 海关编码 ]:
2907199090

补骨脂酚海关

[ 海关编码 ]: 2907199090

[ 中文概述 ]:
2907199090 其他一元酚. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

补骨脂酚文献

Bakuchiol derivatives as novel and potent cytotoxic agents: a report.

Eur. J. Med. Chem. 49C , 55-67, (2012)

A library of 28 compounds comprising of acyl, amino, halo, nitro, styryl and cyclized derivatives of bakuchiol have been evaluated against a panel of eight human cancer cell lines. Bioevaluation studi...

Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.

Planta Med. 78(9) , 903-6, (2012)

Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases. In this study, seven flavonoids were isolated from the methanol extrac...

Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography.

J. Sep. Sci. 30(6) , 813-8, (2007)

Fructus Psoraleae, a widely used traditional Chinese medicine, is well known as a health supplement ingredient. In our study, an improved and comprehensive HPLC fingerprint of Fructus Psoraleae was es...

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