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氰乙酰肼

氰乙酰肼用途

Cyanoacetohydrazide是一种抗结核药物。

氰乙酰肼名称

[ CAS 号 ]:
140-87-4

[ 中文名 ]:
氰乙酰肼

[ 英文名 ]:
Cyanoacetohydrazide

[中文别名 ]:

[英文别名 ]:

UNII-40H59YCS67
Cyacetacide
EINECS 205-437-2
Armazal
Cyanoacetylhydrazine
Dictycide
Cyanoacetic Acid Hydrazide
MFCD00007611
Neohydrazid
Cyanoacetic Hydrazide

氰乙酰肼生物活性

[ 描述 ]:

Cyanoacetohydrazide是一种抗结核药物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

氰乙酰肼物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
405.6±28.0 °C at 760 mmHg

[ 熔点 ]:
108-110 °C(lit.)

[ 分子式 ]:
C₃H₅N₃O

[ 分子量 ]:
99.091

[ 闪点 ]:
199.1±24.0 °C

[ 精确质量 ]:
99.043259

[ PSA ]:
78.91000

[ LogP ]:
-2.16

[ 外观性状 ]:
略棕色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.480

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
水溶性：完全溶解；可溶于：醇；不溶：乙醚

氰乙酰肼MSDS

氰乙酰肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG4200000

CHEMICAL NAME :: Acetic acid, cyano-, hydrazide

CAS REGISTRY NUMBER :: 140-87-4

BEILSTEIN REFERENCE NO. :: 1751498

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H5-N3-O

MOLECULAR WEIGHT :: 99.11

WISWESSER LINE NOTATION :: ZMV1CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 228 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 21,635,1968

氰乙酰肼安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
AG4200000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2928000090

氰乙酰肼合成路线

氰乙酰肼上下游产品

氰乙酰肼上游产品

氰乙酰肼下游产品

氰乙酰肼制备

本品由氰基乙酸乙酯（或甲酯）为原料制得。

氰乙酰肼海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

氰乙酰肼文献

Internal vibrations of a molecule consisting of rigid segments. I. Non-interacting internal vibrations.

Acta Crystallogr. A 49 ( Pt 1) , 10-22, (1993)

For molecular crystals, a procedure is proposed for interpreting experimentally determined atomic mean square anisotropic displacement parameters (ADPs) in terms of the overall molecular vibration tog...

Cyanoacetic acid hydrazones of 3-(and 4-)acetylpyridine and some derived ring systems as potential antitumor and anti-HCV agents.

Arch. Pharm. (Weinheim) 339(1) , 14-23, (2006)

Two new acetylpyridinehydrazones derived from cyanoacetic acid hydrazide have been synthesized namely: cyanoacetic acid (1-pyridin-3 or 4-yl-ethylidene) hydrazides (1a,b). and some derived ring system...

The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities.

Arch. Pharm. Res. 24(5) , 377-84, (2001)

The reaction of either Digitoxin or Digoxin with cyanoacetic acid hydrazide gave the hydrazone derivatives 3a and 3b respectively. The reactivity of the latter products towards chemical reagents was s...

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