Icariside D2

• 常用名: Icariside D2
• 英文名: Icariside D2
• CAS号: 38954-02-8
• 分子量: 300.30400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₂₀O₇
• 熔点: N/A
• 闪点: N/A

Icariside D2用途

Icariside D2 可从Annona glabra 中分离得到,可抑制血管紧张素转换酶。Icariside 对HL-60 细胞的IC50 值为9.0 ± 1.0 μM。Icariside D2 可诱导凋亡。

Icariside D2名称

• 中文名: 淫羊藿次甙 D2
• 英文名: icariside D2

Icariside D2生物活性

• 描述: Icariside D2 可从Annona glabra 中分离得到,可抑制血管紧张素转换酶。Icariside 对HL-60 细胞的IC50 值为9.0 ± 1.0 μM。Icariside D2 可诱导凋亡。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)
  研究领域 >> 炎症/免疫
• 体外研究: 淫羊藿苷d23通过改变凋亡相关蛋白的表达诱导细胞凋亡,降低AKT的磷酸化水平[1]。淫羊藿苷D2具有抗炎和抗HIV活性[3]。
• 参考文献:

  [1]. Nguyen Thi Thu Hien, et al. Chemical Constituents of the Annona Glabra Fruit and Their Cytotoxic Activity. Pharm Biol. 2015;53(11):1602-7.

  [2]. Xue Liu, et al. Metabolic Engineering Escherichia coli for Efficient Production of Icariside D2. Biotechnol Biofuels. 2019 Nov 6;12:261.

  [3]. Jin-YuLi, et al. Three new acylated prenylflavonol glycosides from Epimedium koreanum. Phytochemistry Letters Volume 17, September 2016, Pages 206-212.

Icariside D2物理化学性质

• 分子式: C₁₄H₂₀O₇
• 分子量: 300.30400
• 精确质量: 300.12100
• PSA: 119.61000
• InChIKey: OJDSCNUKKOKOQJ-RKQHYHRCSA-N
• SMILES: OCCc1ccc(OC2OC(CO)C(O)C(O)C2O)cc1
• 外观性状: 粉末
• 储存条件: 室温

Icariside D2安全信息

• 危害码 (欧洲): Xi

Icariside D2靶点实验

查看更多实验

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Icariside D2英文别名

• p-(2'-hydroxyethyl)-phenol β-D-pyranoglucoside
• 2-(4'-β-D-glucopyranosyloxy)-phenylethanol
• 2-(4'-β-glucopyranosyloxy)phenylethanol
• icariside D2
• icariside D2
• salidroside