Cu (OTf) 2-mediated Chan-Lam reaction of carboxylic acids to access phenolic esters

…, G Zhang, M Zhang, J Cheng

Index: Zhang, Lingli; Zhang, Guoying; Zhang, Manli; Cheng, Jiang Journal of Organic Chemistry, 2010 , vol. 75, # 21 p. 7472 - 7474

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Citation Number: 37

Abstract

A Cu (OTf) 2-mediated Chan-Lam reaction of carboxylic acids with arylboronic acids is described. It represents a facile and practical methodology to access phenolic esters in moderate to good yields. The procedure tolerates a series of functional groups, such as methoxycarbonyl, acetoxy, free phenolic hydroxyl, vinyl, nitro, trifluoromethyl, methoxyl, bromo, chloro, iodo, and acetyl groups.

~92%

~82%

~86%

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~51%

~44%

~78%

~61%

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~38%

~85%

~93%

~69%

~10%

~92%

~75%

~87%

~96%

~36%

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