2132961-46-5

2132961-46-5 structure
2132961-46-5 structure
  • Name: PI3Kγ inhibitor 3
  • Chemical Name: PI3Kγ inhibitor 3
  • CAS Number: 2132961-46-5
  • Molecular Formula: C20H23N3O4S2
  • Molecular Weight: 433.54
  • Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
  • Create Date: 2019-06-01 15:32:07
  • Modify Date: 2025-08-26 21:00:33
  • PI3Kγ inhibitor 3 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].

Name PI3Kγ inhibitor 3
Description PI3Kγ inhibitor 3 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].
Related Catalog
Target

PI3Kγ:9.1 (pIC50)

PI3Kα:5.1 (pIC50)

PI3Kβ:4.5 (pIC50)

PI3Kδ:6.5 (pIC50)

PI3KC2α:5 (pIC50)

PI3KC2β:7.5 (pIC50)

PI3KC2γ:5.5 (pIC50)

PI3KC3:5.1 (pIC50)

In Vitro PI3Kγ inhibitor 3 (Compound 15) also inhibits PI3KC2α, PI3KC2β, PI3KC2γ, and PI3KC3 with pIC50s of <5, 7.5, 5.5, and 5.1, respectively[1].
References

[1]. Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. J Med Chem. 2018 Jun 28;61(12):5435-5441.

Molecular Formula C20H23N3O4S2
Molecular Weight 433.54
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