PI3Kγ inhibitor 3

Modify Date: 2024-01-10 18:31:49

PI3Kγ inhibitor 3 structure	Common Name	PI3Kγ inhibitor 3
	CAS Number	2132961-46-5	Molecular Weight	433.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₃N₃O₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI3Kγ inhibitor 3

PI3Kγ inhibitor 3 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].

Name	PI3Kγ inhibitor 3

Description	PI3Kγ inhibitor 3 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	PI3Kγ:9.1 (pIC50) PI3Kα:5.1 (pIC50) PI3Kβ:4.5 (pIC50) PI3Kδ:6.5 (pIC50) PI3KC2α:5 (pIC50) PI3KC2β:7.5 (pIC50) PI3KC2γ:5.5 (pIC50) PI3KC3:5.1 (pIC50)
In Vitro	PI3Kγ inhibitor 3 (Compound 15) also inhibits PI3KC2α, PI3KC2β, PI3KC2γ, and PI3KC3 with pIC50s of <5, 7.5, 5.5, and 5.1, respectively[1].
References	[1]. Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. J Med Chem. 2018 Jun 28;61(12):5435-5441.

Molecular Formula	C₂₀H₂₃N₃O₄S₂
Molecular Weight	433.54

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