MCHR1 antagonist 3

Modify Date: 2025-08-20 09:27:58

MCHR1 antagonist 3 structure	Common Name	MCHR1 antagonist 3
	CAS Number	1069622-60-1	Molecular Weight	472.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₃₆N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MCHR1 antagonist 3

MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism[1].

Name	MCHR1 antagonist 3

Description	MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24) Research Areas >> Metabolic Disease
In Vitro	Compound 1, derived from a spirohydantoin scaffold, exhibits a Ki of 50 nM at MCH-R1. Compound 1 is a potent inhibitor of CYP3A4 (IC50=35 nM). MCHR1 antagonist 3 is an analog of compound 1[1].
References	[1]. Rowbottom MW, et al. Synthesis and structure-activity relationships of spirohydantoin-derived small-moleculeantagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Bioorg Med Chem Lett. 2007 Apr 15;17(8):2171-8.

Molecular Formula	C₂₉H₃₆N₄O₂
Molecular Weight	472.62
InChIKey	RDDNGEWEYVTDBP-UHFFFAOYSA-N
SMILES	CCN1C(=O)N(C2Cc3ccccc3C2)C(=O)C12CCN(Cc1ccc(N3CCCC3)cc1)CC2

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