Isoliquiritin apioside

Modify Date: 2024-01-02 11:57:48

Isoliquiritin apioside structure	Common Name	Isoliquiritin apioside
	CAS Number	120926-46-7	Molecular Weight	550.509
	Density	1.6±0.1 g/cm3	Boiling Point	901.0±65.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₃₀O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	301.9±27.8 °C

Use of Isoliquiritin apioside

Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells[1].

Name	(E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Synonym	More Synonyms

Description	Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP9 NF-κB p38 MAPK
In Vitro	Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity[1].
References	[1]. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.

Density	1.6±0.1 g/cm3
Boiling Point	901.0±65.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₀O₁₃
Molecular Weight	550.509
Flash Point	301.9±27.8 °C
Exact Mass	550.168640
PSA	215.83000
LogP	1.96
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.709

2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-

4-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside

Neolicuroside