Curcumin D6

Modify Date: 2024-01-20 17:14:09

Curcumin D6 structure	Common Name	Curcumin D6
	CAS Number	1246833-26-0	Molecular Weight	374.41700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₄D₆O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Curcumin D6

Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

Name	(1E,6E)-1,7-bis[4-hydroxy-3-(trideuteriomethoxy)phenyl]hepta-1,6-diene-3,5-dione
Synonym	More Synonyms

Description	Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Infection Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Metabolic Disease Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
References	[1]. Gao S, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915(13)004. [2]. Nasiri M, et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14(6):3449-53. [3]. Jiang H, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846(13)00150-4. [4]. Guo H, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013 Jun;68(6):431-4. [5]. Zhu X, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9(3):e91303.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Influenza Virus

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Infection

Signaling Pathways >> Apoptosis >> Ferroptosis

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Autophagy >> Mitophagy

Research Areas >> Metabolic Disease

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

References

[1]. Gao S, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915(13)004.

[2]. Nasiri M, et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14(6):3449-53.

[3]. Jiang H, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846(13)00150-4.

[4]. Guo H, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013 Jun;68(6):431-4.

[5]. Zhu X, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9(3):e91303.

Molecular Formula	C₂₁H₁₄D₆O₆
Molecular Weight	374.41700
Exact Mass	374.16400
PSA	93.06000
LogP	3.36990

Hazard Codes	Xi

Halad-d6

Haidr-d6

Diferuloylmethane-d6

Curcumine-d6

Curcuma-d6

Ukon-d6

Haldar-d6

Curcumin-d6

C Yellow 15-d6

Curcumin D6

Use of Curcumin D6

Names

Curcumin D6 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms