JAK1-IN-31
Modify Date: 2024-06-16 18:49:28
JAK1-IN-31 structure
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Common Name | JAK1-IN-31 | ||
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| CAS Number | 1315498-72-6 | Molecular Weight | 449.529 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JAK1-IN-31JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model. |
| Name | JAK1-IN-31 |
|---|
| Description | JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model. |
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| References | References 1. Zak M, et al. J Med Chem. 2013 Jun 13;56(11):4764-85. View Related Products by Target JAK |
| Molecular Formula | C23H23N5O3S |
|---|---|
| Molecular Weight | 449.529 |