Keap1-Nrf2-IN-12

Modify Date: 2024-01-12 16:00:02

Keap1-Nrf2-IN-12 structure	Common Name	Keap1-Nrf2-IN-12
	CAS Number	2250082-04-1	Molecular Weight	592.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₈N₂O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Keap1-Nrf2-IN-12

Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].

Name	Keap1-Nrf2-IN-12

Description	Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
Target	IC50: 2.30 µM (Keap1-Nrf2)[1].
In Vitro	Keap1-Nrf2-IN-12 (compound 9a) shows metabolic stability in human liver microsomes with slight changes (97.7% remained) after 90 min of incubation[1].
References	[1]. Abed DA, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28(6):115343.

Molecular Formula	C₂₆H₂₈N₂O₁₀S₂
Molecular Weight	592.64

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