Keap1-Nrf2-IN-5

Modify Date: 2024-01-12 08:54:25

Use of Keap1-Nrf2-IN-5

Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1].

Name	Keap1-Nrf2-IN-5

Description	Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
Target	IC50: 4.1 µM (Keap1-Nrf2); Kd: 3.7 µM[1]
References	[1]. Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.

Molecular Formula	C₂₃H₃₀N₄O₆S
Molecular Weight	490.57