Aβ/tau aggregation-IN-1
Modify Date: 2024-01-17 22:13:55
Aβ/tau aggregation-IN-1 structure
|
Common Name | Aβ/tau aggregation-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2252162-81-3 | Molecular Weight | 492.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H21IN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Aβ/tau aggregation-IN-1Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier[1]. |
| Name | Aβ/tau aggregation-IN-1 |
|---|
| Description | Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier[1]. |
|---|---|
| Related Catalog | |
| Target |
Kd: 160 μM (Aβ1-42)[1]. Kd: 337 μM (tau)[1] |
| In Vitro | Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci[1]. Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ1-42 and tau. The KD value of Aβ/tau aggregation-IN-1 with Aβ1-42 is 160 μM. The KD value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ1-42 and tau through noncovalent interactions[1]. Immunofluorescence[1] Cell Line: HEK-293 T cells Concentration: 1 μM Incubation Time: 24 hours Result: Significantly declined the tau aggregation foci. |
| References |
| Molecular Formula | C25H21IN2O |
|---|---|
| Molecular Weight | 492.35 |