Kushenol X

Modify Date: 2024-01-02 11:33:54

Kushenol X Structure
Kushenol X structure
Common Name Kushenol X
CAS Number 254886-77-6 Molecular Weight 440.486
Density 1.3±0.1 g/cm3 Boiling Point 699.6±55.0 °C at 760 mmHg
Molecular Formula C25H28O7 Melting Point N/A
MSDS N/A Flash Point 238.8±25.0 °C

 Use of Kushenol X


Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].

 Names

Name Kushenol X
Synonym More Synonyms

 Kushenol X Biological Activity

Description Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].
Related Catalog
Target

IC50: 2.07 μM (β-glucuronidase)[1] and 3.05 μM (Human carboxylesterase 2 (hCE2))[2]

References

[1]. Cheng-Peng Sun, et al. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase. Int J Biol Macromol. 2020 Jan 15;143:349-358.

[2]. Sha-Sha Song, et al. Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol Macromol. 2019 Jun 15;131:201-208.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 699.6±55.0 °C at 760 mmHg
Molecular Formula C25H28O7
Molecular Weight 440.486
Flash Point 238.8±25.0 °C
Exact Mass 440.183502
PSA 127.45000
LogP 5.74
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.640

 Safety Information

Hazard Codes Xi

 Synonyms

4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-8-[5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2R,3R)-
(2R,3R)-2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-2,3-dihydro-4H-chromen-4-one
Kushenol X
(2R,3R)-2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-(2-isopropenyl-5-methyl-4-hexen-1-yl)-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2R,3R)-
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