Hydroxy-PEG6-CH2-Boc

Modify Date: 2024-01-10 08:31:18

Hydroxy-PEG6-CH2-Boc Structure
Hydroxy-PEG6-CH2-Boc structure
Common Name Hydroxy-PEG6-CH2-Boc
CAS Number 297162-47-1 Molecular Weight 396.473
Density 1.1±0.1 g/cm3 Boiling Point 469.5±40.0 °C at 760 mmHg
Molecular Formula C18H36O9 Melting Point N/A
MSDS N/A Flash Point 151.3±20.8 °C

 Use of Hydroxy-PEG6-CH2-Boc


Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosan-1-oate
Synonym More Synonyms

 Hydroxy-PEG6-CH2-Boc Biological Activity

Description Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 469.5±40.0 °C at 760 mmHg
Molecular Formula C18H36O9
Molecular Weight 396.473
Flash Point 151.3±20.8 °C
Exact Mass 396.235931
LogP -0.96
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.456

 Synonyms

2-Methyl-2-propanyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosan-1-oate
3,6,9,12,15,18-Hexaoxaeicosan-1-oic acid, 20-hydroxy-, 1,1-dimethylethyl ester
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