5,7-Dihydroxychromone

Modify Date: 2024-01-05 17:04:28

5,7-Dihydroxychromone Structure
5,7-Dihydroxychromone structure
Common Name 5,7-Dihydroxychromone
CAS Number 31721-94-5 Molecular Weight 178.141
Density 1.6±0.1 g/cm3 Boiling Point 399.4±42.0 °C at 760 mmHg
Molecular Formula C9H6O4 Melting Point 232-273℃
MSDS N/A Flash Point 170.8±21.4 °C

 Use of 5,7-Dihydroxychromone


5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells[1].

 Names

Name 5,7-dihydroxychromen-4-one
Synonym More Synonyms

 5,7-Dihydroxychromone Biological Activity

Description 5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells[1].
Related Catalog
Target

Nrf2

Caspase-3

Caspase-9

PARP

References

[1]. Kim DW, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015 Jun 1;130:25-30.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 399.4±42.0 °C at 760 mmHg
Melting Point 232-273℃
Molecular Formula C9H6O4
Molecular Weight 178.141
Flash Point 170.8±21.4 °C
Exact Mass 178.026611
PSA 70.67000
LogP 0.54
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.689

 Safety Information

Hazard Codes Xi
HS Code 2914400090

 Synthetic Route

~5%

5,7-Dihydroxychromone Structure

5,7-Dihydroxych...

CAS#:31721-94-5

Literature: Li, Su-Yi; Wang, Xiao-Bing; Xie, Sai-Sai; Jiang, Neng; Wang, Kelvin D.G.; Yao, He-Quan; Sun, Hong-Bin; Kong, Ling-Yi European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 632 - 646

~93%

5,7-Dihydroxychromone Structure

5,7-Dihydroxych...

CAS#:31721-94-5

Literature: Zheng, Shu-Yan; Li, Xiao-Ping; Tan, Hong-Sheng; Yu, Chun-Hui; Zhang, Jing-Hua; Shen, Zheng-Wu European Journal of Organic Chemistry, 2013 , # 7 p. 1356 - 1366

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5,7-Dihydroxychromone Structure

5,7-Dihydroxych...

CAS#:31721-94-5

Literature: Jain, A. C.; Gupta, S. M.; Tyagi, O. D. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1036 - 1039

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5,7-Dihydroxychromone Structure

5,7-Dihydroxych...

CAS#:31721-94-5

Literature: Organic Preparations and Procedures International, , vol. 23, # 3 p. 390 - 392

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5,7-Dihydroxychromone Structure

5,7-Dihydroxych...

CAS#:31721-94-5

Literature: Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 28, # 5 p. 497 - 502 Khimiya Geterotsiklicheskikh Soedinenii, Sbornik, , # 5 p. 595 - 600

~%

5,7-Dihydroxychromone Structure

5,7-Dihydroxych...

CAS#:31721-94-5

Literature: Jain, A. C.; Gupta, S. M.; Tyagi, O. D. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1036 - 1039

~%

5,7-Dihydroxychromone Structure

5,7-Dihydroxych...

CAS#:31721-94-5

Literature: Organic Preparations and Procedures International, , vol. 23, # 3 p. 390 - 392

 Customs

HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

4H-1-Benzopyran-4-one, 5,7-dihydroxy-
5,7-dihydroxy-4H-1-benzopyran-4-one
5,7-Dihydroxychromone
2H-1-Benzopyran-2-one, 5,7-dihydroxy-
5,7-Dihydroxy-4H-chromen-4-one
5,7-Dihydroxy-2H-chromen-2-one
5,7-dihydroxy-chromen-4-one
5,7-Dihydroxy-chromen-4-on
5,7-DIHYDROXYCOUMARIN
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