Hydrangenol
Hydrangenol structure
|
Common Name | Hydrangenol | ||
|---|---|---|---|---|
| CAS Number | 480-47-7 | Molecular Weight | 256.253 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 528.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H12O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 206.4±23.6 °C | |
Use of HydrangenolHydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | hydrangenol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1]. |
|---|---|
| Related Catalog | |
| Target |
MMP-1 MMP-3 COX-2 IL-6 |
| In Vivo | Hydrangenol (5, 10, 20, 或 40 mg/kg; 口服; 每日给药，共 7 周) 减轻 uvb 照射 HR-1 无毛小鼠的皱纹形成、背厚、脱水和胶原蛋白降解[1]。 Animal Model: UVB-irradiated HR-1 hairless mice[1] Dosage: 5, 10, 20, or 40 mg/kg Administration: Oral gavage; daily for 7 weeks Result: Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Increased the expression of Pro-COL1A1. Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6). Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1). Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC). |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 528.3±50.0 °C at 760 mmHg |
| Molecular Formula | C15H12O4 |
| Molecular Weight | 256.253 |
| Flash Point | 206.4±23.6 °C |
| Exact Mass | 256.073547 |
| PSA | 66.76000 |
| LogP | 2.54 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.662 |
| InChIKey | DGKDFNDHPXVXHW-UHFFFAOYSA-N |
| SMILES | O=C1OC(c2ccc(O)cc2)Cc2cccc(O)c21 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 3 | |
CAS#:82780-51-6
CAS#:637774-32-4
CAS#:1093748-41-4![4-[(tert-Butyldimethylsilyl)oxy]benzaldehyde Structure](https://image.chemsrc.com/caspic/194/120743-99-9.png)
CAS#:120743-99-9
CAS#:67600-94-6
CAS#:4397-53-9
CAS#:1798-09-0
CAS#:100-66-3
CAS#:117970-24-8
CAS#:118842-88-9
CAS#:567-61-3
CAS#:99-96-7
CAS#:80458-94-2This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one |
| Hydrangenol |
| 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-isochromen-1-one |
| 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one |
| UNII:TL8PI7PHV1 |
| 8-Hydroxy-3-(4-hydroxy-phenyl)-isochroman-1-one |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does hydrangenol have? |
| A: English synonyms of hydrangenol: 3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one, Hydrangenol, 8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-isochromen-1-one, 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one, UNII:TL8PI7PHV1, 8-Hydroxy-3-(4-hydroxy-phenyl)-isochroman-1-one. |
| Q: What are the upstream materials of hydrangenol? |
| A: Related upstream materials(CAS) of hydrangenol: 82780-51-6;637774-32-4;1093748-41-4;120743-99-9;67600-94-6;4397-53-9;1798-09-0;100-66-3;117970-24-8;118842-88-9. |
| Q: What is the InChIKey of hydrangenol? |
| A: InChIKey of hydrangenol is DGKDFNDHPXVXHW-UHFFFAOYSA-N. |
| Q: What is the LogP of hydrangenol? |
| A: LogP of hydrangenol is 2.54. |
| Q: What is the boiling point of hydrangenol? |
| A: Boiling point of hydrangenol is 528.3±50.0 °C at 760 mmHg. |
| Q: What is the polar surface area (PSA) of hydrangenol? |
| A: Polar surface area (PSA) of hydrangenol is 66.76000. |
| Q: What is the molecular formula of hydrangenol? |
| A: Molecular formula of hydrangenol is C15H12O4. |
| Q: What is the CAS number of hydrangenol? |
| A: CAS number of hydrangenol is 480-47-7. |
| Q: What is the SMILES notation of hydrangenol? |
| A: SMILES notation of hydrangenol is O=C1OC(c2ccc(O)cc2)Cc2cccc(O)c21. |
| Q: What is the molecular weight of hydrangenol? |
| A: Molecular weight of hydrangenol is 256.253. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |