Hydrangenol

Modify Date: 2025-08-22 19:05:19

Hydrangenol Structure
Hydrangenol structure
 Common Name Hydrangenol
CAS Number 480-47-7 Molecular Weight 256.253
Density 1.4±0.1 g/cm3 Boiling Point 528.3±50.0 °C at 760 mmHg
Molecular Formula C15H12O4 Melting Point N/A
MSDS N/A Flash Point 206.4±23.6 °C

 Use of Hydrangenol


Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].

 Names

Name hydrangenol
Synonym More Synonyms

 Hydrangenol Biological Activity

Description Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].
Related Catalog
Target

MMP-1

MMP-3

COX-2

IL-6

In Vivo Hydrangenol (5, 10, 20, 或 40 mg/kg; 口服; 每日给药，共 7 周) 减轻 uvb 照射 HR-1 无毛小鼠的皱纹形成、背厚、脱水和胶原蛋白降解[1]。 Animal Model: UVB-irradiated HR-1 hairless mice[1] Dosage: 5, 10, 20, or 40 mg/kg Administration: Oral gavage; daily for 7 weeks Result: Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Increased the expression of Pro-COL1A1. Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6). Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1). Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).
References

[1]. Myung DB, et al. Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice. Nutrients. 2019 Oct 2;11(10):2354.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 528.3±50.0 °C at 760 mmHg
Molecular Formula C15H12O4
Molecular Weight 256.253
Flash Point 206.4±23.6 °C
Exact Mass 256.073547
PSA 66.76000
LogP 2.54
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.662
InChIKey DGKDFNDHPXVXHW-UHFFFAOYSA-N
SMILES O=C1OC(c2ccc(O)cc2)Cc2cccc(O)c21

 Safety Information

Hazard Codes Xi

 Synthetic Route

 HydrangenolBioassay

View more

Name: Decrease in IL6 gene expression in mouse 3T3L1 cells at 30 uM after 2 days relative t...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924258
Name: Decrease in IL6 gene expression in mouse 3T3L1 cells at 100 uM after 2 days relative ...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924259
Name: Increase in adiponectin gene expression in mouse 3T3L1 cells at 100 uM after 2 days r...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924253
Name: Increase in PPARgamma2 gene expression in mouse 3T3L1 cells at 30 uM after 2 days rel...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924255
Name: Increase in PPARgamma2 gene expression in mouse 3T3L1 cells at 100 uM after 2 days re...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924256
Name: Increase in 2-Deoxyglucose-uptake in mouse 3T3L1 cells at 3 uM by liquid scintillatio...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924265
Name: Tested for inhibitory activity against B lymphocyte proliferation induced by LPS at 1...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL648518
Name: Increase in 2-Deoxyglucose-uptake in mouse 3T3L1 cells at 10 uM by liquid scintillati...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924266
Name: Increase in 2-Deoxyglucose-uptake in mouse 3T3L1 cells at 30 uM by liquid scintillati...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924267
Name: Increase in 2-Deoxyglucose-uptake in mouse 3T3L1 cells at 100 uM by liquid scintillat...
Source: ChEMBL
Target: 3T3-L1
External Id: CHEMBL924268
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 Synonyms

3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one
Hydrangenol
8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-isochromen-1-one
8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
UNII:TL8PI7PHV1
8-Hydroxy-3-(4-hydroxy-phenyl)-isochroman-1-one
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Chemsrc provides Hydrangenol(CAS#:480-47-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Hydrangenol are included as well.>> amp version: Hydrangenol

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