Ph-PEG3

Modify Date: 2024-01-23 14:30:01

Ph-PEG3 Structure
Ph-PEG3 structure
Common Name Ph-PEG3
CAS Number 7204-16-2 Molecular Weight 226.26900
Density 1.097g/cm3 Boiling Point 351.9ºC at 760 mmHg
Molecular Formula C12H18O4 Melting Point N/A
MSDS N/A Flash Point 166.6ºC

 Use of Ph-PEG3


Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-(2-phenoxyethoxy)ethoxy]ethanol
Synonym More Synonyms

 Ph-PEG3 Biological Activity

Description Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.097g/cm3
Boiling Point 351.9ºC at 760 mmHg
Molecular Formula C12H18O4
Molecular Weight 226.26900
Flash Point 166.6ºC
Exact Mass 226.12100
PSA 47.92000
LogP 1.09090
Index of Refraction 1.504

 Synthetic Route

~71%

Ph-PEG3 Structure

Ph-PEG3

CAS#:7204-16-2

Literature: Kimura, Masaru; Kajita, Kazushige; Onoda, Naoyuki; Morosawa, Shiro Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4887 - 4892

~65%

Ph-PEG3 Structure

Ph-PEG3

CAS#:7204-16-2

Literature: Jursic, Branko Tetrahedron, 1988 , vol. 44, # 5 p. 1553 - 1558

~%

Detail
Literature: DOW GLOBAL TECHNOLOGIES INC. Patent: WO2009/76275 A1, 2009 ; Location in patent: Page/Page column 13-15 ;

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Ph-PEG3 Structure

Ph-PEG3

CAS#:7204-16-2

Literature: Mertens, Ingrid J. A.; Wegh, Rene; Jenneskens, Leonardus W.; Vlietstra, Edward J.; Van Der Kerk-van Hoof, Anca; Zwikker, Jan W.; Cleij, Thomas J.; Smeets, Wilberth J. J.; Veldman, Nora; Spek, Anthony L. Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 3 p. 725 - 736

~%

Ph-PEG3 Structure

Ph-PEG3

CAS#:7204-16-2

Literature: Jursic, Branko Tetrahedron, 1988 , vol. 44, # 5 p. 1553 - 1558

~%

Detail
Literature: DOW GLOBAL TECHNOLOGIES INC. Patent: WO2009/76275 A1, 2009 ; Location in patent: Page/Page column 13-15 ;

~%

Ph-PEG3 Structure

Ph-PEG3

CAS#:7204-16-2

Literature: Shukis; Tallman Journal of the American Chemical Society, 1944 , vol. 66, p. 1462

~%

Ph-PEG3 Structure

Ph-PEG3

CAS#:7204-16-2

Literature: Miller et al. Journal of the Chemical Society, 1950 , p. 3623,3628

~%

Ph-PEG3 Structure

Ph-PEG3

CAS#:7204-16-2

Literature: I.G. Farbenind. Patent: DE519730 , 1925 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 561

 Synonyms

2-(2-Hydroxy-aethoxy)-1-(2-phenoxy-aethoxy)-aethan
[2-(2-Hydroxy-aethoxy)-aethyl]-(2-phenoxy-aethyl)-aether
2-[2-(2-phenoxy-ethoxy)-ethoxy]-ethanol
8-phenoxy-3,6-dioxa-1-octanol
2-[2-(2-phenoxyethoxy)ethoxy]ethan-1-ol
Ethanol,2-[2-(2-phenoxyethoxy)ethoxy]
triethylene glycol phenyl ether
2-[2-(2-Phenoxy-aethoxy)-aethoxy]-aethanol
bis[2-(2-hydroxyethoxy)ethoxy]benzene
TRIETHYLENE GLYCOL MONOPHENYL ETHER
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