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盐酸托烷司琼

盐酸托烷司琼用途

Tropisetron是5-HT3受体拮抗剂和α7-烟碱受体激动剂,对5-HT3受体的IC50为70.1 nM。

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盐酸托烷司琼名称

[ CAS 号 ]:
105826-92-4

[ 中文名 ]:
1H-吲哚-3-羧酸-(3-endo)-8-甲基-8-氮杂双环[3,2,1]辛烷-3-基酯盐酸盐

[ 英文名 ]:
Tropisetron hydrochloride

[中文别名 ]:

盐酸托烷司琼

[英文别名 ]:

Tropisetron HCl
Tropisetron monohydrochloride
Navoban
MFCD02313825
Tropisetron hydrochloride
Novaban
Tropisetron (Hydrochloride)

盐酸托烷司琼生物活性

[ 描述 ]:

Tropisetron是5-HT3受体拮抗剂和α7-烟碱受体激动剂,对5-HT3受体的IC50为70.1 nM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

[参考文献]

[1]. Rahimian R, et al. Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest. 2013 Oct;43(10):1039-51.

[2]. Swartz MM, et al. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology. 2013 Oct;73:111-21.

[3]. Aminian A, et al. Tropisetron diminishes demyelination and disease severity in an animal model of multiple sclerosis. Neuroscience. 2013 Jun 15;248C:299-306.

[4]. Rahimian R, et al. Tropisetron upregulates cannabinoid CB1 receptors in cerebellar granule cells: possible involvement of calcineurin. Brain Res. 2011 Oct 12;1417:1-8.

[相关活性小分子]

盐酸托烷司琼物理化学性质

[ 沸点 ]:
448.5ºC at 760 mmHg

[ 熔点 ]:
283-285ºC

[ 分子式 ]:
C₁₇H₂₁ClN₂O₂

[ 分子量 ]:
320.814

[ 闪点 ]:
225ºC

[ 精确质量 ]:
320.129150

[ PSA ]:
41.90000

[ LogP ]:
2.83000

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
3.09E-08mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
可溶于：甲醇

盐酸托烷司琼MSDS

详细MSDS(安全技术说明书)

盐酸托烷司琼安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

盐酸托烷司琼文献

Determination of tropisetron in human plasma by high performance liquid chromatographic method with UV detection and its application to a bioequivalence study.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 846(1-2) , 20-3, (2007)

A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected ont...

Inhibition of 5-hydroxytryptamine- and enterotoxin-induced fluid secretion by 5-HT receptor antagonists in the rat jejunum.

Eur. J. Pharmacol. 248 , 157, (1993)

The effects of cholera toxin and heat stable Escherichia coli (E. coli) enterotoxin on intestinal fluid secretion are commonly considered to be mediated by cyclic nucleotides. It was demonstrated rece...

Effects of 5-hydroxytryptamine 3 receptor antagonists on gastrointestinal motor activity in conscious dogs.

J. Pharmacol. Exp. Ther. 256 , 272, (1991)

We studied the effect of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists on gastrointestinal (GI) motor activity in conscious dogs with force transducers implanted chronically. During the digestive...

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盐酸托烷司琼

盐酸托烷司琼用途

盐酸托烷司琼名称

盐酸托烷司琼生物活性

盐酸托烷司琼物理化学性质

盐酸托烷司琼MSDS

详细MSDS(安全技术说明书)

盐酸托烷司琼安全信息

盐酸托烷司琼文献

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