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盐酸阿洛司琼

盐酸阿洛司琼用途

Alosetron是5-HT3受体拮抗剂,可作用于肠易激综合征。

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盐酸阿洛司琼名称

[ CAS 号 ]:
122852-69-1

[ 中文名 ]:
盐酸阿洛司琼

[ 英文名 ]:
Alosetron hydrochloride

[中文别名 ]:

[英文别名 ]:

Alosetron hydrochloride
gr 68755c
LOTRONEX
MFCD03453647
Alosetron HCl
GR-68755C
Alosetron (Hydrochloride)

盐酸阿洛司琼生物活性

[ 描述 ]:

Alosetron是5-HT3受体拮抗剂,可作用于肠易激综合征。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

[参考文献]

[1]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74.

[2]. Lucak SL. Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72.

[3]. Lewis JH. Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29.

[4]. Turgeon DK, Tayeh N, Fontana RJ. Acute hepatitis associated with alosetron (Lotronex). J Clin Gastroenterol. 2005 Aug;39(7):641-2.

[5]. Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM. Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride. Am J Gastroenterol. 2003 May;98(5):1117-22.

[相关活性小分子]

盐酸阿洛司琼物理化学性质

[ 密度 ]:
1.34g/cm3

[ 沸点 ]:
648.1ºC at 760 mmHg

[ 熔点 ]:
288-291ºC

[ 分子式 ]:
C₁₇H₁₉ClN₄O

[ 分子量 ]:
330.812

[ 闪点 ]:
345.8ºC

[ 精确质量 ]:
330.124725

[ PSA ]:
53.92000

[ LogP ]:
3.14820

[ 外观性状 ]:
灰白色粉末

[ 蒸汽压 ]:
1.1E-16mmHg at 25°C

[ 储存条件 ]:
Refrigerator

盐酸阿洛司琼MSDS

详细MSDS(安全技术说明书)

盐酸阿洛司琼安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319-H411

[ 警示性声明 ]:
P273-P301 + P310-P305 + P351 + P338

[ 危害码 (欧洲) ]:
T,Xi

[ 风险声明 (欧洲) ]:
25-36-52/53

[ 安全声明 (欧洲) ]:
26-45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933990090

盐酸阿洛司琼海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸阿洛司琼文献

In silico binary classification QSAR models based on 4D-fingerprints and MOE descriptors for prediction of hERG blockage.

J. Chem. Inf. Model. 50(7) , 1304-18, (2010)

Blockage of the human ether-a-go-go related gene (hERG) potassium ion channel is a major factor related to cardiotoxicity. Hence, drugs binding to this channel have become an important biological end ...

Quantitative benefit-risk assessment using only qualitative information on utilities.

Med. Decis. Making 32(6) , E1-15, (2012)

Utilities of pertinent clinical outcomes are crucial variables for assessing the benefits and risks of drugs, but numerical data on utilities may be unreliable or altogether missing. We propose a meth...

Clinical trials in irritable bowel syndrome: a review.

Rev. Recent Clin. Trials 8(1) , 9-22, (2013)

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and it is characterized by episodes of abdominal pain and altered bowel functions. The specific bowel disturbances o...

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