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维生素A醋酸酯

维生素A醋酸酯用途

Retinyl acetate 是维生素 A 的天然形式,具有潜在的抗肿瘤和化学预防活性。

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维生素A醋酸酯名称

[ CAS 号 ]:
127-47-9

[ 中文名 ]:
维生素A醋酸酯

[ 英文名 ]:
Retinyl acetate

[中文别名 ]:

[英文别名 ]:

Retinol, acetate, all-trans-
all-trans-Retinyl acetate
Retinyl acetate, all-trans-
Vitamin A acetate (VAN)
all-trans-Vitamin A acetate
VITAMIN A1 ACETATE
Retinyl acetate
MFCD00019413
trans-Vitamin A acetate
Retinol acetate,Retinyl acetate,Vitamin A acetate

维生素A醋酸酯生物活性

[ 描述 ]:

Retinyl acetate 是维生素 A 的天然形式,具有潜在的抗肿瘤和化学预防活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 其他

[参考文献]

[1]. Moon, Richard C, et al. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea. Nature. 1977 Jun 16;267(5612):620-1.

[相关活性小分子]

维生素A醋酸酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
440.5±14.0 °C at 760 mmHg

[ 熔点 ]:
57-58 °C

[ 分子式 ]:
C₂₂H₃₂O₂

[ 分子量 ]:
328.488

[ 闪点 ]:
124.8±18.5 °C

[ 精确质量 ]:
328.240234

[ PSA ]:
26.30000

[ LogP ]:
7.39

[ 外观性状 ]:
结晶

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
soluble

维生素A醋酸酯MSDS

详细MSDS(安全技术说明书)

维生素A醋酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH6825000

CHEMICAL NAME :: Retinol, acetate

CAS REGISTRY NUMBER :: 127-47-9

BEILSTEIN REFERENCE NO. :: 1915439

LAST UPDATED :: 199701

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C22-H32-O2

MOLECULAR WEIGHT :: 328.54

WISWESSER LINE NOTATION :: L6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 432 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6352 ku/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6347 mg/kg/21D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Blood - changes in platelet count Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2208 mg/kg/21D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 51800 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 95 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 480 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 310 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1377 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - respiratory system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1377 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 826 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1205 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 310 mg/kg

SEX/DURATION :: female 9-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 100 umol/L

REFERENCE :: ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 44,356,1987 *** REVIEWS *** TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB-275-754 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80572 No. of Facilities: 277 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80572 No. of Facilities: 550 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 13296 (estimated) No. of Female Employees: 7092 (estimated)

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维生素A醋酸酯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360-H413

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R38;R63

[ 安全声明 (欧洲) ]:
S36/37-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
VH6825000

[ 海关编码 ]:
2936210000

维生素A醋酸酯合成路线

详细合成路线

维生素A醋酸酯上下游产品

维生素A醋酸酯上游产品

维生素A醋酸酯下游产品

维生素A醋酸酯海关

[ 海关编码 ]: 2936210000

维生素A醋酸酯文献

Simultaneous analysis for water- and fat-soluble vitamins by a novel single chromatography technique unifying supercritical fluid chromatography and liquid chromatography.

J. Chromatogr. A. 1362 , 270-7, (2014)

Chromatography techniques usually use a single state in the mobile phase, such as liquid, gas, or supercritical fluid. Chromatographers manage one of these techniques for their purpose but are sometim...

Effects of microbial phytase on apparent and standardized total tract digestibility of calcium in calcium supplements fed to growing pigs.

J. Anim. Sci. 93 , 2255-64, (2015)

An experiment was conducted to test the hypothesis that differences in the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of Ca exist among Ca supplements ...

Ultra-performance liquid chromatographic determination of tocopherols and retinol in human plasma.

J. Chromatogr. Sci. 52(9) , 1065-70, (2014)

A rapid, selective and sensitive ultra-performance liquid chromatography method has been developed for the detection and quantification of tocopherols and retinol in human plasma. Alpha-tocopherol, ga...

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