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磺胺甲基嘧啶

磺胺甲基嘧啶用途

Sulfamerazine(RP-2632)是磺胺类抗菌素。

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磺胺甲基嘧啶作用

磺胺甲基嘧啶（RP-2632）是一种磺胺类抗菌剂。通过与对氨基苯甲酸（PABA）竞争结合二氢蝶酸合成酶（二氢叶酸合成酶）来抑制细菌合成二氢叶酸。磺胺甲基嘧啶在性质上是抑菌的。抑制二氢叶酸的合成会减少细菌核苷酸和DNA的合成。

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磺胺甲基嘧啶名称

[ CAS 号 ]:
127-79-7

[ 中文名 ]:
磺胺甲基嘧啶

[ 英文名 ]:
Sulfamerazine

[中文别名 ]:

磺胺甲嘧啶

[英文别名 ]:

2-sulfanilamido-4-methylpyrimidine
Mesulfa
Mebacid
SMI
A-310
METSULFA
Romezin
sulfamerazine
Sulfamerazin
RP 2632

磺胺甲基嘧啶生物活性

[ 描述 ]:

Sulfamerazine(RP-2632)是磺胺类抗菌素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. HALL, W.H. and W.W. SPINK, Sulfamerazine: clinical evaluation in 116 cases. Journal of the American Medical Association, 1943. 123(3): p. 125-131.

[相关活性小分子]

磺胺甲基嘧啶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
519.1±52.0 °C at 760 mmHg

[ 熔点 ]:
234-238°C

[ 分子式 ]:
C₁₁H₁₂N₄O₂S

[ 分子量 ]:
264.304

[ 闪点 ]:
267.8±30.7 °C

[ 精确质量 ]:
264.068085

[ PSA ]:
106.35000

[ LogP ]:
0.34

[ 外观性状 ]:
白色或淡黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.660

[ 储存条件 ]:
库房通风低温干燥

磺胺甲基嘧啶MSDS

磺胺甲基嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0750000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)-

CAS REGISTRY NUMBER :: 127-79-7

BEILSTEIN REFERENCE NO. :: 0249133

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C11-H12-N4-O2-S

MOLECULAR WEIGHT :: 264.33

WISWESSER LINE NOTATION :: T6N CNJ BMSWR DZ& D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1890 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 27,141,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 211,367,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,213,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 27,141,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 45020 mg/kg/17D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 17934 mg/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 81,259,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 6-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 101,362,1951 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80539 No. of Facilities: 963 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 4216 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80539 No. of Facilities: 48 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 707 (estimated) No. of Female Employees: 507 (estimated)

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磺胺甲基嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WP0750000

[ 海关编码 ]:
2935009090

磺胺甲基嘧啶合成路线

磺胺甲基嘧啶上下游产品

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磺胺甲基嘧啶下游产品

磺胺甲基嘧啶海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

磺胺甲基嘧啶文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1345 , 17-28, (2014)

A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) p...

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磺胺甲基嘧啶

磺胺甲基嘧啶用途

磺胺甲基嘧啶作用

磺胺甲基嘧啶名称

磺胺甲基嘧啶生物活性

磺胺甲基嘧啶物理化学性质

磺胺甲基嘧啶MSDS

详细MSDS(安全技术说明书)

磺胺甲基嘧啶毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

磺胺甲基嘧啶安全信息

磺胺甲基嘧啶合成路线

详细合成路线

磺胺甲基嘧啶上下游产品

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磺胺甲基嘧啶文献

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