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新橙皮苷

新橙皮苷用途

Neohesperidin是一种大量存在于葫芦科植物中的类黄酮化合物,具有抗氧化和抗炎作用的。

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新橙皮苷名称

[ CAS 号 ]:
13241-33-3

[ 中文名 ]:
新橙皮苷

[ 英文名 ]:
Neohesperidin

[中文别名 ]:

[英文别名 ]:

HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
hesperetin 7-O-neohesperoside
Neohesperidin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
Hesperetin 7-O-neohesperidoside

新橙皮苷生物活性

[ 描述 ]:

Neohesperidin是一种大量存在于葫芦科植物中的类黄酮化合物,具有抗氧化和抗炎作用的。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

天然产物 >> 黄酮类化合物

[体外研究]

新橙皮苷在人乳腺癌MDA-MB-231细胞中诱导细胞凋亡。新橙皮苷在24和48小时的IC50值分别为47.4±2.6μM和32.5±1.8μM。新橙皮苷处理的细胞中P53和Bax的表达显着上调,而Bcl-2的表达则下调[1]。新橙皮苷在DPPH自由基清除试验中表现出抗氧化活性(IC50 =22.31μg/ mL)[2]。

[体内研究]

新橙皮苷(50mg/kg)显着抑制55.0％的HCl /乙醇诱导的胃损伤。在幽门结扎大鼠中,新橙皮苷(50mg/kg)显着降低胃分泌和胃酸输出量,并增加pH [1]。新橙皮苷的治疗显着降低小鼠的空腹血糖,血糖和糖基化血清蛋白(GSP)。它显着提高了口服葡萄糖耐量和胰岛素敏感性,并降低了糖尿病小鼠的胰岛素抵抗。新橙皮苷显着降低小鼠的血清甘油三酯,总胆固醇,瘦素水平和肝脏指数[3]。

[动物实验]

小鼠：所有小鼠在测试前6小时禁食，然后通过强饲法喂食水或新橙皮苷。对于OGTT和ITT，分别向小鼠腹膜内注射2g / kg BW葡萄糖或1IU / kg BW胰岛素。从尾静脉收集血样用于在注射葡萄糖或胰岛素之前测量基础血糖水平（0分钟）。在30,60,90和120分钟测量额外的血糖水平[3]。

[参考文献]

[1]. Lee JH, et al. Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytother Res. 2009 Dec;23(12):1748-53.

[2]. Xu F, et al. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. Nat Prod Commun. 2012 Nov;7(11):1475-8.

[3]. Jia S, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) mice. Food Funct. 2015 Mar;6(3):878-86.

[相关活性小分子]

新橙皮苷物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
933.7±65.0 °C at 760 mmHg

[ 熔点 ]:
239-243ºC

[ 分子式 ]:
C₂₈H₃₄O₁₅

[ 分子量 ]:
610.561

[ 闪点 ]:
306.7±27.8 °C

[ 精确质量 ]:
610.189758

[ PSA ]:
234.29000

[ LogP ]:
2.44

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.695

[ 储存条件 ]:
2-8°C

新橙皮苷MSDS

详细MSDS(安全技术说明书)

新橙皮苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2981400

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)- beta-D- glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyp henyl)-, (S)-

CAS REGISTRY NUMBER :: 13241-33-3

BEILSTEIN REFERENCE NO. :: 0074945

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H34-O15

MOLECULAR WEIGHT :: 610.62

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新橙皮苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DJ2981400

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新橙皮苷上游产品

新橙皮苷下游产品

新橙皮苷文献

Comparative metabolic and transcriptional analysis of a doubled diploid and its diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) suggests its potential value for stress resistance improvement.

BMC Plant Biol. 15 , 89, (2015)

Polyploidy has often been considered to confer plants a better adaptation to environmental stresses. Tetraploid citrus rootstocks are expected to have stronger stress tolerance than diploid. Plenty of...

Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells.

Chin. Med. 10 , 14, (2015)

Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) exhibited potential anti-tumor effects with unclear underlying mechanisms. This study aims to evaluate the potential anti-metastatic acti...

Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium).

Food Chem. Toxicol. 71 , 176-82, (2014)

Inhibiting microglial activation-mediated neuroinflammation has become a convincing target for the development of functional foods to treat neurodegenerative diseases. Tangerine peel (Citri reticulata...

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