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阿普洛尔

阿普洛尔用途

Alprenolol是一个非选择性的beta阻断剂,也是5-HT1A受体的拮抗剂。

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阿普洛尔名称

[ CAS 号 ]:
13655-52-2

[ 中文名 ]:
阿普洛尔

[ 英文名 ]:
Alprenolol

[中文别名 ]:

心得舒

[英文别名 ]:

Alpheprol
Alprenolol
ALLPRENOLOL

阿普洛尔生物活性

[ 描述 ]:

Alprenolol是一个非选择性的beta阻断剂,也是5-HT1A受体的拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 癌症

[参考文献]

[1]. Schreiber R et al. Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):211-5.

[2]. Millan MJ et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther, 1994 Jan, 2

[相关活性小分子]

阿普洛尔物理化学性质

[ 密度 ]:
1.007g/cm3

[ 沸点 ]:
383.4ºC at 760mmHg

[ 熔点 ]:
57.5°C

[ 分子式 ]:
C₁₅H₂₃NO₂

[ 分子量 ]:
249.34900

[ 闪点 ]:
185.7ºC

[ 精确质量 ]:
249.17300

[ PSA ]:
41.49000

[ LogP ]:
2.54370

[ 蒸汽压 ]:
1.46E-06mmHg at 25°C

[ 折射率 ]:
1.5250 (estimate)

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

阿普洛尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA5350000

CHEMICAL NAME :: 2-Propanol, 1-(o-allylphenoxy)-3-(isopropylamino)-

CAS REGISTRY NUMBER :: 13655-52-2

LAST UPDATED :: 199606

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H23-N-O2

MOLECULAR WEIGHT :: 249.39

WISWESSER LINE NOTATION :: 1Y1&M1YQ1OR B2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UGLAAD Ugeskrift for Laeger. Doctor's Weekly. (Almindelige Danske Laegeforening, Esplanaden 8C4, 1045 Copenhagen K, Denmark) V.1- 1839- Volume(issue)/page/year: 139,2817,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 18,151,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1022,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 8,137,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 8,137,1974

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阿普洛尔安全信息

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

阿普洛尔

阿普洛尔用途

阿普洛尔名称

阿普洛尔生物活性

阿普洛尔物理化学性质

阿普洛尔毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

阿普洛尔安全信息

阿普洛尔合成路线

详细合成路线

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