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鹅膏氨酸

鹅膏氨酸用途

Ibotenic acid 对 N-甲基-D-天冬氨酸 (NMDA) 和反式-ACPD 或代谢型使君子氨酸 (Q_m) 受体位点都具有激动剂活性。

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鹅膏氨酸名称

[ CAS 号 ]:
2552-55-8

[ 中文名 ]:
鹅膏氨酸

[ 英文名 ]:
Ibotenic acid

[中文别名 ]:

鹅膏蕈氨酸

[英文别名 ]:

Ibotenic acid
5-Isoxazoleacetic acid, α-amino-2,3-dihydro-3-oxo-
a-Amino-3-hydroxy-5-isoxazoleacetic Acid
a-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic Acid
MFCD00069294
Amino-(3-hydroxy-5-isoxazolyl)acetic acid
2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid

鹅膏氨酸生物活性

[ 描述 ]:

Ibotenic acid 对 N-甲基-D-天冬氨酸 (NMDA) 和反式-ACPD 或代谢型使君子氨酸 (Qm) 受体位点都具有激动剂活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

天然产物 >> 酸和醛

研究领域 >> 神经疾病

[ 靶点 ]

NMDA receptor[1]

[体外研究]

尽管只有NMDA受体的活化参与Ibo神经毒性,但是Ibotenic acid(Ibo)能够作用于CNS中的NMDA和反式ACPD受体。通过乳酸脱氢酶释放到培养基中测量,Ibotenic酸对皮质神经元有毒,暴露5分钟,EC50 = 77.3±8μM(n = 5)[1]。

[参考文献]

[1]. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10.

[相关活性小分子]

鹅膏氨酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
458.8±45.0 °C at 760 mmHg

[ 熔点 ]:
141-147 °C

[ 分子式 ]:
C₅H₆N₂O₄

[ 分子量 ]:
158.112

[ 闪点 ]:
231.3±28.7 °C

[ 精确质量 ]:
158.032761

[ PSA ]:
109.58000

[ LogP ]:
-1.07

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.610

[ 储存条件 ]:
-20°C

鹅膏氨酸MSDS

鹅膏氨酸安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S45-S38-S36/37/39-S28A-S22

[ 危险品运输编码 ]:
1544

[ RTECS号 ]:
NY2100000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

鹅膏氨酸合成路线

鹅膏氨酸上下游产品

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鹅膏氨酸制备

由蛤蟆菌(Amanita pantherian DC.)中提取得的一种含异噁唑环的氨基酸，也是捕蝇口蘑(A. muscaria L.)中能杀死苍蝇的有效成分。

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鹅膏氨酸文献

Audition-independent vocal crystallization associated with intrinsic developmental gene expression dynamics.

J. Neurosci. 35(3) , 878-89, (2015)

Complex learned behavior is influenced throughout development by both genetic and environmental factors. Birdsong, like human speech, is a complex vocal behavior acquired through sensorimotor learning...

Assessment of sensorimotor gating following selective lesions of cholinergic pedunculopontine neurons.

Eur. J. Neurosci. 40(10) , 3526-37, (2014)

Sensorimotor gating is the state-dependent transfer of sensory information into a motor system. When this occurs at an early stage of the processing stream it enables stimuli to be filtered out or par...

Dopamine D2 Modulation of Sign and Goal Tracking in Rats.

Neuropsychopharmacology 40 , 2096-102, (2015)

In Pavlovian conditioning, sign- and goal-tracking behaviors represent different approaches towards the conditioned stimulus. These behavioral patterns have been associated with predictive or incentiv...

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