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2-羟基-3-甲基丁酸

2-羟基-3-甲基丁酸用途

2-Hydroxy-3-methylbutanoic 是 GHB 的一个结构类似物,GHB 是一种中枢神经系统中发现的天然物质,也是一种神经药物。

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2-羟基-3-甲基丁酸名称

[ CAS 号 ]:
4026-18-0

[ 中文名 ]:
2-羟基-3-甲基丁酸

[ 英文名 ]:
2-Hydroxy-3-methylbutyric acid

[中文别名 ]:

2-羟基异戊酸

[英文别名 ]:

D-Valic acid
D-2-HYDROXY-3-METHYLBUTYRIC ACID
A-hydroxyisovaleric acid
DL-2-Hydroxyisovaleric acid
2-HYDROXY-3-METHYLBU
α-hydroxyisovaleric acid
MFCD00004242
Einecs 223-697-5
UNII:02X1W97FWN
DL-a-hydroxyisovaleric acid

2-羟基-3-甲基丁酸生物活性

[ 描述 ]:

2-Hydroxy-3-methylbutanoic 是 GHB 的一个结构类似物,GHB 是一种中枢神经系统中发现的天然物质,也是一种神经药物。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Pan YM, et al. Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. J Anal Toxicol. 2001 Jul-Aug;25(5):328-32.

[相关活性小分子]

2-羟基-3-甲基丁酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
237.6±13.0 °C at 760 mmHg

[ 熔点 ]:
86-87ºC(lit.)

[ 分子式 ]:
C₅H₁₀O₃

[ 分子量 ]:
118.131

[ 闪点 ]:
111.8±16.3 °C

[ 精确质量 ]:
118.062996

[ PSA ]:
57.53000

[ LogP ]:
0.18

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.455

[ 储存条件 ]:
室温

2-羟基-3-甲基丁酸MSDS

2-羟基-3-甲基丁酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918199090

2-羟基-3-甲基丁酸合成路线

2-羟基-3-甲基丁酸上下游产品

2-羟基-3-甲基丁酸上游产品

2-羟基-3-甲基丁酸下游产品

2-羟基-3-甲基丁酸制备

1. 烟草：OR，26；FC，40。

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2-羟基-3-甲基丁酸海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

2-羟基-3-甲基丁酸文献

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain

Brain Res. 1324 , 75-84, (2010)

Patients affected by maple syrup urine disease (MSUD) present severe neurological symptoms and brain abnormalities, whose pathoiphysiology is poorly known. In the present study we investigated the in ...

Renal clearance of branched-chain L-amino and 2-oxo acids in maple syrup urine disease.

J. Inherit. Metab. Dis. 22(6) , 706-22, (1999)

In maple syrup urine disease (MSUD), branched-chain L-amino (BCAA) and 2-oxo acids (BCOA) accumulate in body fluids owing to an inherited deficiency of branched-chain 2-oxo acid dehydrogenase complex ...

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