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2-丁酮酸

2-丁酮酸用途

2-Oxobutanoic acid 是胱硫醚的酶促裂解产物。

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2-丁酮酸名称

[ CAS 号 ]:
600-18-0

[ 中文名 ]:
2-酮丁酸

[ 英文名 ]:
2-Oxobutyric acid

[中文别名 ]:

[英文别名 ]:

Butanoic acid, 2-oxo-
EINECS 209-986-9
α-oxobutyric acid
2-oxo-Butyric acid
a-keto-n-butyric acid
MFCD00004164
methyl-Pyruvic acid
propionyl- Formic acid
a-Oxobutyric acid
2-Oxobutyric acid

2-丁酮酸生物活性

[ 描述 ]:

2-Oxobutanoic acid 是胱硫醚的酶促裂解产物。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

2-氧代丁酸(α-酮丁酸)是胱硫醚的酶促裂解产物。 2-氧代丁酸是一种参与许多氨基酸代谢以及丙酸代谢和C-5支链二元酸代谢的物质。 2-氧代丁酸也是苏氨酸的降解产物之一。它可以转化为丙酰辅酶A(随后甲基丙二酰辅酶A,它可以转化为琥珀酰辅酶A,柠檬酸循环中间体),从而进入柠檬酸循环[1]。

[参考文献]

[1]. CARROLL WR, et al. alpha-Ketobutyric acid as a product in the enzymatic cleavage of cystathionine. J Biol Chem. 1949 Aug;180(1):375-82.

[相关活性小分子]

2-丁酮酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
177.8±0.0 °C at 760 mmHg

[ 熔点 ]:
30-34 °C(lit.)

[ 分子式 ]:
C₄H₆O₃

[ 分子量 ]:
102.089

[ 闪点 ]:
65.0±15.2 °C

[ 精确质量 ]:
102.031693

[ PSA ]:
54.37000

[ LogP ]:
-0.71

[ 外观性状 ]:
无色糊

[ 蒸汽压 ]:
0.5±0.6 mmHg at 25°C

[ 折射率 ]:
1.427

[ 储存条件 ]:
−20°C

2-丁酮酸MSDS

2-丁酮酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
1759

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2918300090

2-丁酮酸合成路线

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2-丁酮酸上游产品

2-丁酮酸下游产品

2-丁酮酸海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

2-丁酮酸文献

Mosquito odorant receptor for DEET and methyl jasmonate.

Proc. Natl. Acad. Sci. U. S. A. 111(46) , 16592-7, (2014)

Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbe...

Kinetic resolution of 2-hydroxybutanoate racemic mixtures by NAD-independent L-lactate dehydrogenase.

Bioresour. Technol. 102(7) , 4595-9, (2011)

Optically active D-2-hydroxybutanoate is an important building block intermediate for medicines and biodegradable poly(2-hydroxybutanoate). Kinetic resolution of racemic 2-hydroxybutanoate may be a gr...

Transaminase-catalyzed asymmetric synthesis of L-2-aminobutyric acid from achiral reactants.

Biotechnol. Lett. 31 , 1595-1599, (2009)

Asymmetric synthesis of an unnatural amino acid was demonstrated by omega-transaminase from Vibrio fluvialis JS17. L-2-Aminobutyric acid was synthesized from 2-oxobutyric acid and benzylamine with an ...

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