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膦胺霉素钠盐

膦胺霉素钠盐用途

Fosmidomycin sodium salt 是一种磷酸抗生素和抗疟疾药,对革兰氏阴性菌和革兰氏阳性菌均有活性。

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膦胺霉素钠盐名称

[ CAS 号 ]:
66508-37-0

[ 中文名 ]:
膦胺霉素

[ 英文名 ]:
Fosmidomycin sodium salt

[英文别名 ]:

膦胺霉素钠盐生物活性

[ 描述 ]:

Fosmidomycin sodium salt 是一种磷酸抗生素和抗疟疾药,对革兰氏阴性菌和革兰氏阳性菌均有活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[体外研究]

Fosmidomycin钠盐是一种膦酸抗生素[1] [2],对革兰氏阴性菌和革兰氏阳性菌都有活性[3]。

[体内研究]

用剂量> 10mg/kg的fosmidomycin腹膜内处理的动物显然没有寄生虫。用5mg/kg的fosmidomycin处理后,寄生虫病<1％。用50或100mg/kg的fosmidomycin口服治疗的动物显然没有寄生虫,并且用20mg/kg药物治疗后寄生虫病<1％。当治疗在4天后终止时观察到复发。在8天的时间内用30mg/kg的fosmidomycin处理的小鼠完全治愈[3]。

[参考文献]

[1]. Kojo H, et al. FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. J Antibiot (Tokyo). 1980 Jan;33(1):44-8.

[2]. Fernandes JF, et al. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90.

[3]. Jomaa H, et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6.

[相关活性小分子]

膦胺霉素钠盐物理化学性质

[ 沸点 ]:
463.7ºC at 760 mmHg

[ 熔点 ]:
189-191ºC

[ 分子式 ]:
C₄H₉NNaO₅P

[ 分子量 ]:
205.08

[ 闪点 ]:
234.3ºC

[ PSA ]:
82.70000

[ LogP ]:
0.34710

[ 储存条件 ]:
-20°C

膦胺霉素钠盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ8554000

CHEMICAL NAME :: Phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt

CAS REGISTRY NUMBER :: 66508-37-0

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H9-N-O5-P.Na

MOLECULAR WEIGHT :: 205.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-40720

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 19(5),668,1985

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膦胺霉素钠盐安全信息

[ 海关编码 ]:
2931900090

膦胺霉素钠盐合成路线

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膦胺霉素钠盐上下游产品

膦胺霉素钠盐上游产品

膦胺霉素钠盐下游产品

膦胺霉素钠盐海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%