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盐酸去甲维拉帕米

盐酸去甲维拉帕米用途

Norverapamil是一个钙通道阻滞剂, 是verapamil主要的活性代谢物。

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盐酸去甲维拉帕米名称

[ CAS 号 ]:
67812-42-4

[ 中文名 ]:
盐酸去甲维拉帕米

[ 英文名 ]:
Norverapamil hydrochloride

[中文别名 ]:

去甲维拉帕米盐酸盐

[英文别名 ]:

N-Nor-(+/-)-verapamil hydrochloride
Nor Verapamil Hydrochloride
Norverapamil hydrochloride
Norverapamil (hydrochloride)

盐酸去甲维拉帕米生物活性

[ 描述 ]:

Norverapamil是一个钙通道阻滞剂, 是verapamil主要的活性代谢物。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 心血管疾病

[参考文献]

[1]. Adams KN et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.

[2]. Singhal P et al. Enantiomeric separation of verapamil and its active metabolite, norverapamil, and simultaneous quantification in human plasma by LC-ESI-MS-MS. J Chromatogr Sci. 2012 Oct;50(9):839-48.

[3]. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302.

[相关活性小分子]

盐酸去甲维拉帕米物理化学性质

[ 熔点 ]:
155-160â„ƒ dec.

[ 分子式 ]:
C₂₆H₃₇ClN₂O₄

[ 分子量 ]:
477.04

[ LogP ]:
2.02400

[ 储存条件 ]:
2-8℃

盐酸去甲维拉帕米MSDS

详细MSDS(安全技术说明书)

盐酸去甲维拉帕米安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

盐酸去甲维拉帕米文献

Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs.

J. Infect. Dis. 210(3) , 456-66, (2014)

Drug tolerance likely represents an important barrier to tuberculosis treatment shortening. We previously implicated the Mycobacterium tuberculosis efflux pump Rv1258c as mediating macrophage-induced ...

Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.

J. Pharm. Sci. 102(9) , 3161-73, (2013)

Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo. The overall aim of our study was to investigate the inhibitory potential of...

Stereoselective CZE method for analysis of verapamil and norverapamil in human plasma.

Acta Pol. Pharm. 70(3) , 395-401, (2013)

A stereospecific capillary zone electrophoresis (CZE) method was developed for the determination of verapamil (VER) and its main metabolite norverapamil (NOR) in human plasma. Optimal temperature, cyc...

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