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串珠镰刀菌素

串珠镰刀菌素用途

Moniliformin sodium salt是提取自镰孢镰刀菌中的有效,水溶性的霉菌毒素。

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串珠镰刀菌素名称

[ CAS 号 ]:
71376-34-6

[ 中文名 ]:
串珠镰刀菌素

[ 英文名 ]:
Moniliformin, sodium salt

[英文别名 ]:

3-CYCLOBUTENE-1,2-DIONE,3-HYDROXY-,SODIUM SALT
1-Hydroxycyclobut-1-ene-3,4-dione
3-Hydroxy-3-cyclobutenedione sodium salt
Moniliformin sodium salt
1-Hydroxycyclobut-1-ene-3,4-dione sodium salt
Moniliformin (sodium salt)

串珠镰刀菌素生物活性

[ 描述 ]:

Moniliformin sodium salt是提取自镰孢镰刀菌中的有效,水溶性的霉菌毒素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[体外研究]

Fusarium moniliforme NRRL 6322每kg玉米砂粒培养基产生约600mg可回收的moniliformin,一种霉菌毒性代谢物。几种Fusarium moniliforme菌株在实验室培养中每千克生长基质产生超过800毫克的moniliformin [1]。在分化过程中暴露于moniliformin的单核细胞衍生的巨噬细胞表现出内吞作用能力的降低,以及CD71和HLA-DR表达的降低[2]。

[体内研究]

Moniliformin对小鼠的毒性较小,女性的LD50为每公斤20.9毫克,男性为每公斤体重29.1毫克。与小鸡的情况一样,在毒素中存活的小鼠没有表现出任何不良影响;死后的小鼠或小鸡在治疗后4至6小时内卧位,并在24小时内死亡。在4日龄鸡胚中,获得了每个胚胎2.8微克的尖锐LD50,幸存者没有明显的致畸作用[1]。用最高剂量的念尼泊定治疗的大鼠显示活性降低,然后是急性心力衰竭和死亡。较低剂量(<9mg/kg体重)的大鼠未显示出毒性迹象。每日摄入的moniliformin强烈降低了所有剂量组中嗜中性粒细胞的吞噬活性。在随访期间,卫星组继续减少,表明对免疫系统有严重影响,而对于念珠菌素,LOAEL值为3mg/kg体重。 Moniliformin迅速排泄到尿液中,每日摄入量在20.2％至31.5％之间,并且没有积累的迹象。粪便中moniliformin的浓度小于2％,这表明从胃肠道有效吸收[3]。

[动物实验]

大鼠：Moniliformin在水中制备。在该实验中，将5个剂量组（3,6,9,12和15mg / kg moniliformin bw）的试验动物暴露于moniliformin 28天。每组由5只雄性Sprague-Dawley大鼠组成。剂量组基于我们对大鼠MON的急性毒性研究确定。另外，使用给予过滤自来水和两个卫星组（给药12和15mg / kg体重的moniliformin）的对照组。两个卫星组在没有治疗的情况下再保持14天，以检测可能的延迟毒性作用并跟踪恢复情况[3]。小鼠：将念珠菌素的无菌水溶液腹膜内（0.2mL）注射到5只雌性和5只雄性白色小鼠中，每只体重约25g，浓度相当于每kg体重0,20,25,30和35mg。在4天的时间内观察小鼠，并测定LD 50值[1]。

[参考文献]

[1]. Burmeister HR, et al. Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Appl Environ Microbiol. 1979 Jan;37(1):11-3.

[2]. Ficheux AS, et al. Effects of beauvericin, enniatin b and moniliformin on human dendritic cells and macrophages: an in vitro study. Toxicon. 2013 Sep;71:1-10.

[3]. Jonsson M, et al. Repeated dose 28-day oral toxicity study of moniliformin in rats. Toxicol Lett. 2015 Feb 17;233(1):38-44.

[相关活性小分子]

串珠镰刀菌素物理化学性质

[ 沸点 ]:
239.6ºC at 760 mmHg

[ 分子式 ]:
C₄HNaO₃

[ 分子量 ]:
120.03900

[ 闪点 ]:
113ºC

[ 精确质量 ]:
119.98200

[ PSA ]:
57.20000

[ 储存条件 ]:
Store at 2-8

串珠镰刀菌素MSDS

详细MSDS(安全技术说明书)

串珠镰刀菌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU1815000

CHEMICAL NAME :: 3-Cyclobutene-1,2-dione, 3-hydroxy-, sodium salt

CAS REGISTRY NUMBER :: 71376-34-6

LAST UPDATED :: 199503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H-O3.Na

MOLECULAR WEIGHT :: 120.04

WISWESSER LINE NOTATION :: L4VVJ CO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 37,11,1979

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串珠镰刀菌素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ RTECS号 ]:
GU1815000

串珠镰刀菌素文献

Characterization and mycotoxigenic potential of Fusarium species in freshly harvested and stored sugar beet in Europe.

Phytopathology 101(11) , 1330-7, (2011)

Based on a 2-year field trial at two locations in Lower Saxony (Germany), 395 Fusarium isolates belonging to 13 species were collected from more than 3,000 sugar beet roots that were apparently health...

Emerging fusarium-mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin: a review.

Crit. Rev. Food Sci. Nutr 48(1) , 21-49, (2008)

The contamination of foods and feed with mycotoxins is a commonly known problem. Intense investigations have been conducted to study the occurrence, toxicity, and recently also the prevention and deto...

Mycotoxin production by isolates of Fusarium lactis from greenhouse sweet pepper (Capsicum annuum).

Int. J. Food Microbiol. 151(2) , 150-6, (2011)

Internal fruit rot, caused by Fusarium lactis, is an important disease of sweet pepper (Capsicum annuum) in Canadian greenhouses. Production of the mycotoxins fumonisin B₁ (FB₁), moniliformin (MON) an...

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